Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3660608..3661302 Replicon chromosome
Accession NZ_CP009844
Organism Yersinia pestis strain Dodson

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag CH61_RS17710 Protein ID WP_002214787.1
Coordinates 3660608..3660904 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag CH61_RS17715 Protein ID WP_002209924.1
Coordinates 3660904..3661302 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH61_RS17675 3655730..3657247 + 1518 WP_002209930.1 lysine--tRNA ligase -
CH61_RS17685 3657680..3658894 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
CH61_RS17690 3658976..3659161 - 186 WP_002209928.1 hypothetical protein -
CH61_RS17700 3659759..3660019 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
CH61_RS17705 3660082..3660444 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
CH61_RS17710 3660608..3660904 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
CH61_RS17715 3660904..3661302 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
CH61_RS17720 3661702..3663993 - 2292 WP_002209923.1 toprim domain-containing protein -
CH61_RS17725 3664293..3664619 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
CH61_RS25260 3664612..3664764 + 153 WP_002209921.1 hypothetical protein -
CH61_RS17735 3664778..3664978 - 201 WP_002209920.1 AlpA family transcriptional regulator -
CH61_RS17740 3665160..3665492 - 333 WP_002214791.1 hypothetical protein -
CH61_RS17745 3665498..3665734 - 237 WP_002214792.1 hypothetical protein -
CH61_RS17750 3665747..3666112 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T49972 WP_002214787.1 NZ_CP009844:3660608-3660904 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T49972 NZ_CP009844:3660608-3660904 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT49972 WP_002209924.1 NZ_CP009844:3660904-3661302 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT49972 NZ_CP009844:3660904-3661302 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References