Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3404663..3405357 Replicon chromosome
Accession NZ_CP009840
Organism Yersinia pestis A1122

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag CH57_RS16040 Protein ID WP_002214787.1
Coordinates 3405061..3405357 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag CH57_RS16035 Protein ID WP_002209924.1
Coordinates 3404663..3405061 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH57_RS16000 3399853..3400218 + 366 WP_002209919.1 hypothetical protein -
CH57_RS16005 3400231..3400467 + 237 WP_002214792.1 hypothetical protein -
CH57_RS16010 3400473..3400805 + 333 WP_002214791.1 hypothetical protein -
CH57_RS16015 3400987..3401187 + 201 WP_002209920.1 AlpA family transcriptional regulator -
CH57_RS24425 3401201..3401353 - 153 WP_002209921.1 hypothetical protein -
CH57_RS16025 3401346..3401672 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
CH57_RS16030 3401972..3404263 + 2292 WP_002209923.1 toprim domain-containing protein -
CH57_RS16035 3404663..3405061 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
CH57_RS16040 3405061..3405357 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
CH57_RS16045 3405521..3405883 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
CH57_RS16050 3405946..3406206 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
CH57_RS16060 3406804..3406989 + 186 WP_002209928.1 hypothetical protein -
CH57_RS16065 3407071..3408285 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
CH57_RS16075 3408718..3410235 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T49948 WP_002214787.1 NZ_CP009840:c3405357-3405061 [Yersinia pestis A1122]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T49948 NZ_CP009840:c3405357-3405061 [Yersinia pestis A1122]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT49948 WP_002209924.1 NZ_CP009840:c3405061-3404663 [Yersinia pestis A1122]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT49948 NZ_CP009840:c3405061-3404663 [Yersinia pestis A1122]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References