Detailed information of TA system TA049936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 3769703..3770248
• Replicon: chromosome
• Accession: NZ_CP009838
• Organism: Yersinia enterocolitica strain 2516-87

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: CH48_RS17180
• Protein ID: WP_042663920.1
• Coordinates: 3769970..3770248 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A7T9Y052
• Locus tag: CH48_RS17175
• Protein ID: WP_005161466.1
• Coordinates: 3769703..3769963 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH48_RS17145	3764864..3766039	-	1176	WP_042663918.1	phage tail sheath protein	-
CH48_RS17150	3766349..3766534	-	186	WP_013649738.1	hypothetical protein	-
CH48_RS22300	3766668..3766806	-	139	Protein_3230	ash family protein	-
CH48_RS17155	3767098..3767982	-	885	WP_072077075.1	Rpn family recombination-promoting nuclease/putative transposase	-
CH48_RS23035	3768188..3768364	-	177	WP_013649740.1	hypothetical protein	-
CH48_RS17160	3768806..3769126	-	321	WP_013649741.1	hypothetical protein	-
CH48_RS17165	3769116..3769322	-	207	WP_013649742.1	hypothetical protein	-
CH48_RS23040	3769464..3769631	+	168	WP_005161469.1	hypothetical protein	-
CH48_RS17175	3769703..3769963	+	261	WP_005161466.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CH48_RS17180	3769970..3770248	+	279	WP_042663920.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
CH48_RS21845	3770301..3770913	-	613	Protein_3238	tail fiber assembly protein	-
CH48_RS17195	3770913..3772205	-	1293	WP_013649744.1	phage tail protein	-
CH48_RS22955	3772178..3772459	-	282	WP_013649745.1	phage tail protein	-
CH48_RS17205	3772452..3772997	-	546	WP_032904715.1	phage tail protein I	-
CH48_RS17210	3772990..3773898	-	909	WP_013649747.1	baseplate assembly protein	-
CH48_RS17215	3773898..3774254	-	357	WP_005161449.1	GPW/gp25 family protein	-
CH48_RS17220	3774251..3774886	-	636	WP_013649748.1	phage baseplate assembly protein V	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	pilW	3758240..3801504	43264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10887.61 Da
• Isoelectric Point: 9.6247

>T49936 WP_042663920.1 NZ_CP009838:3769970-3770248 [Yersinia enterocolitica]
MTKQREIEYSGQFQKDVKKAQKRHKDINKLKTIMALLIDDKLPLPVIYKDHQLQGNYKGYRDAHIEPDWLIIYKITDDLL
LFGRTGSHSDLF

Nucleotide

• Length: 279 bp

>T49936 NZ_CP009838:3769970-3770248 [Yersinia enterocolitica]
ATGACTAAACAAAGGGAAATTGAATATTCAGGTCAGTTCCAGAAAGATGTGAAAAAAGCTCAGAAGCGCCATAAAGATAT
AAATAAACTTAAAACTATTATGGCGCTGCTAATTGACGATAAATTACCCTTGCCTGTTATATACAAGGATCATCAATTAC
AAGGTAATTACAAAGGTTACAGGGATGCGCATATAGAGCCAGACTGGCTTATCATCTACAAGATTACTGATGATTTGCTT
CTCTTCGGAAGGACAGGAAGCCATTCTGATCTATTTTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9277.75 Da
• Isoelectric Point: 7.0134

>AT49936 WP_005161466.1 NZ_CP009838:3769703-3769963 [Yersinia enterocolitica]
MAANAFVRARIDETLKNEAAAVLAGMGLTVSDLVRITLTKVAREKALPFDLRIPNELTAKTIANSEKGVDVHKAKDADDL
FDKLGI

Nucleotide

• Length: 261 bp

>AT49936 NZ_CP009838:3769703-3769963 [Yersinia enterocolitica]
ATGGCTGCAAATGCTTTTGTTCGTGCTCGTATAGATGAAACCCTAAAAAATGAAGCCGCTGCTGTGCTTGCTGGCATGGG
TTTAACCGTATCCGATCTGGTGCGGATAACCTTAACCAAGGTCGCCCGAGAAAAAGCGCTTCCGTTCGATTTGCGTATTC
CTAACGAACTTACCGCTAAAACTATTGCCAACAGCGAGAAAGGTGTCGATGTCCACAAAGCAAAGGATGCCGATGATCTG
TTTGATAAATTAGGTATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7T9Y052