Detailed information of TA system TA049918

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1395794..1396517
• Replicon: chromosome
• Accession: NZ_CP009831
• Organism: Burkholderia multivorans ATCC BAA-247

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: NP80_RS08455
• Protein ID: WP_006409059.1
• Coordinates: 1395794..1396114 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9BI88
• Locus tag: NP80_RS08460
• Protein ID: WP_006403504.1
• Coordinates: 1396116..1396517 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NP80_RS08440	1392546..1394087	+	1542	WP_167338149.1	sensor domain-containing diguanylate cyclase	-
NP80_RS08445	1394293..1394565	+	273	WP_006403506.1	hypothetical protein	-
NP80_RS08450	1394666..1395700	+	1035	WP_006397017.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
NP80_RS08455	1395794..1396114	+	321	WP_006409059.1	type II toxin-antitoxin system MqsR family toxin	Toxin
NP80_RS08460	1396116..1396517	+	402	WP_006403504.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
NP80_RS08465	1396806..1397366	+	561	WP_006409062.1	GNAT family N-acetyltransferase	-
NP80_RS08470	1397432..1398373	+	942	WP_006409064.1	ABC transporter substrate-binding protein	-
NP80_RS08475	1398405..1399466	+	1062	WP_006403500.1	LLM class flavin-dependent oxidoreductase	-
NP80_RS08480	1399463..1400815	+	1353	WP_006409061.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (20-105)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12024.04 Da
• Isoelectric Point: 9.0721

>T49918 WP_006409059.1 NZ_CP009831:1395794-1396114 [Burkholderia multivorans ATCC BAA-247]
MVTLAHGYLWKSERRTASCRVKALIEAGKVRLTASAVIGARLMGFTEAEAIDVVRALTPFEFHKSMTTYADHTIWQDVYR
PCTMRGDVYLKLTVVDDVLIVSFKER

Nucleotide

• Length: 321 bp

>T49918 NZ_CP009831:1395794-1396114 [Burkholderia multivorans ATCC BAA-247]
TTGGTTACACTCGCGCATGGATACCTATGGAAAAGCGAACGCCGCACTGCAAGCTGCCGCGTCAAGGCGCTGATCGAAGC
CGGCAAGGTCCGCCTGACCGCAAGCGCCGTCATCGGCGCCCGCCTGATGGGCTTCACCGAAGCGGAAGCGATCGACGTGG
TGAGGGCGCTGACACCGTTCGAATTCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGG
CCTTGCACGATGCGCGGCGACGTGTACCTGAAACTGACCGTCGTCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATA
A

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT49918 WP_006403504.1 NZ_CP009831:1396116-1396517 [Burkholderia multivorans ATCC BAA-247]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT49918 NZ_CP009831:1396116-1396517 [Burkholderia multivorans ATCC BAA-247]
ATGAAATGTCCTGCATGCGGTGCTGCCACGCTGGTCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACATCACCGGCGAGTTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGACGAGGCGACCCGTTTCG
GCGAAGCGGTGTCGGCGTTCAACCGGCAGGTGAACGCGACACTCGTCGATCCGAAGTTCATTGCGACGGTACGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCACCGCTGGCGCTCGTGAAGCTGCTGAAGATTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGTGCGGCAT
AA

Structures

Antitoxin

• AlphaFold DB: B9BI88