Detailed information of TA system TA049913

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2443017..2443726
• Replicon: chromosome
• Accession: NZ_CP009829
• Organism: Xylella fastidiosa strain 3124

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: Q9PAL4
• Locus tag: XFC3_RS11155
• Protein ID: WP_010894925.1
• Coordinates: 2443017..2443319 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: XFC3_RS11160
• Protein ID: WP_088572655.1
• Coordinates: 2443322..2443726 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFC3_RS11130	2438175..2439353	-	1179	WP_023907007.1	phage tail sheath family protein	-
XFC3_RS11135	2439418..2441010	-	1593	WP_023907008.1	tail fiber domain-containing protein	-
XFC3_RS11140	2441018..2441575	-	558	WP_023907009.1	phage tail protein I	-
XFC3_RS11145	2441568..2442461	-	894	WP_023907762.1	baseplate J/gp47 family protein	-
XFC3_RS11150	2442461..2442799	-	339	WP_088372106.1	GPW/gp25 family protein	-
XFC3_RS11155	2443017..2443319	+	303	WP_010894925.1	type II toxin-antitoxin system MqsR family toxin	Toxin
XFC3_RS11160	2443322..2443726	+	405	WP_088572655.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
XFC3_RS11165	2443795..2444382	-	588	WP_023907016.1	phage baseplate assembly protein V	-
XFC3_RS11170	2444379..2444921	-	543	WP_023907017.1	hypothetical protein	-
XFC3_RS11175	2444897..2445418	-	522	WP_088572623.1	hypothetical protein	-
XFC3_RS11180	2445415..2445738	-	324	WP_031336752.1	hypothetical protein	-
XFC3_RS11185	2445738..2445998	-	261	WP_010893239.1	hypothetical protein	-
XFC3_RS11190	2446016..2447896	-	1881	WP_023907020.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2424784..2474697	49913

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10958.74 Da
• Isoelectric Point: 8.0251

>T49913 WP_010894925.1 NZ_CP009829:2443017-2443319 [Xylella fastidiosa]
MEKGTPHYKLPVVKALVKAGKVRATATAYQGARELGIKDLTGMCTVVLALTSADFYKSMTTYADHTVFQDVYHAKTASGD
EVYLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 303 bp

>T49913 NZ_CP009829:2443017-2443319 [Xylella fastidiosa]
ATGGAGAAAGGCACACCCCACTACAAGCTACCAGTCGTCAAAGCCTTGGTAAAAGCTGGCAAGGTCAGGGCTACAGCGAC
CGCCTACCAAGGAGCACGTGAGCTTGGCATCAAAGATTTAACTGGAATGTGCACCGTTGTCTTGGCGCTCACGTCTGCCG
ACTTCTACAAGAGCATGACGACCTACGCGGATCACACAGTATTCCAGGATGTGTACCACGCCAAGACGGCAAGCGGTGAT
GAGGTGTACCTGAAGTTAACTGTCATTGATGACGTGTTGATTGTTTCCTTCAAGGAGTTATGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15117.28 Da
• Isoelectric Point: 7.1650

>AT49913 WP_088572655.1 NZ_CP009829:2443322-2443726 [Xylella fastidiosa]
MRCPCCGAAELIHDTRDMLYTYKSETTSIPTVTGDFCPACGEVVLDREHGDRYSELLVGLFQRQVNSAYVDPGYITKVRR
KLDLDQRQAAELFGGGVNAFSRYENGKTKPPLSLVKLFKLLDRHPDLLNEVKSF

Nucleotide

• Length: 405 bp

>AT49913 NZ_CP009829:2443322-2443726 [Xylella fastidiosa]
ATGAGATGTCCATGCTGCGGCGCGGCAGAACTGATCCACGACACGCGCGACATGCTTTACACCTATAAGAGCGAAACTAC
TAGTATCCCAACGGTGACCGGCGACTTCTGCCCGGCGTGTGGCGAAGTCGTCTTGGACCGTGAACATGGTGATCGTTACA
GCGAATTATTGGTCGGCTTGTTCCAACGTCAGGTGAATTCGGCCTACGTCGATCCTGGTTACATTACCAAGGTACGCCGG
AAGCTTGATCTCGACCAGCGGCAAGCTGCCGAACTGTTCGGTGGTGGTGTTAATGCTTTCTCACGTTACGAGAACGGTAA
AACCAAGCCGCCGCTGTCTTTGGTTAAGTTATTCAAGCTTCTGGATCGCCACCCCGATTTGCTCAACGAAGTGAAGAGTT
TCTAA

Structures

Toxin

• AlphaFold DB: Q9PAL4