Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2374833..2375017 Replicon chromosome
Accession NZ_CP009828
Organism Staphylococcus aureus strain MS4

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag NI36_RS12020 Protein ID WP_000482647.1
Coordinates 2374910..2375017 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2374833..2374893 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NI36_RS12010 2370741..2372474 - 1734 WP_000488493.1 ABC transporter ATP-binding protein/permease -
NI36_RS12015 2372550..2374262 - 1713 WP_001064821.1 ABC transporter ATP-binding protein/permease -
NI36_RS14610 2374716..2374883 - 168 WP_000301893.1 hypothetical protein -
- 2374833..2374893 + 61 - - Antitoxin
NI36_RS12020 2374910..2375017 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
NI36_RS12025 2375150..2375536 - 387 WP_000779353.1 flippase GtxA -
NI36_RS12030 2375804..2376946 + 1143 WP_001176863.1 glycerate kinase -
NI36_RS12035 2377006..2377665 + 660 WP_000831298.1 membrane protein -
NI36_RS12040 2377848..2379059 + 1212 WP_001191921.1 multidrug effflux MFS transporter -
NI36_RS12045 2379182..2379655 - 474 WP_000456483.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2368748..2370394 1646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T49907 WP_000482647.1 NZ_CP009828:c2375017-2374910 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T49907 NZ_CP009828:c2375017-2374910 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT49907 NZ_CP009828:2374833-2374893 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References