Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2347645..2348162 Replicon chromosome
Accession NZ_CP009828
Organism Staphylococcus aureus strain MS4

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag NI36_RS11875 Protein ID WP_000113263.1
Coordinates 2347645..2347911 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NI36_RS11880 Protein ID WP_000584499.1
Coordinates 2347911..2348162 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NI36_RS11850 2342905..2343441 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
NI36_RS11855 2343854..2344678 - 825 WP_000594633.1 formate/nitrite transporter family protein -
NI36_RS11860 2344882..2345064 - 183 WP_000079140.1 hypothetical protein -
NI36_RS11865 2345151..2345618 - 468 WP_000153338.1 SRPBCC domain-containing protein -
NI36_RS11870 2345804..2347351 - 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NI36_RS11875 2347645..2347911 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
NI36_RS11880 2347911..2348162 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NI36_RS11885 2348335..2348426 - 92 Protein_2267 hypothetical protein -
NI36_RS11890 2348433..2349032 - 600 WP_000162810.1 DsbA family protein -
NI36_RS11895 2349051..2349413 - 363 WP_000819839.1 DUF4467 domain-containing protein -
NI36_RS11900 2349668..2350918 + 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
NI36_RS11905 2351015..2351746 - 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
NI36_RS11910 2351743..2352462 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T49906 WP_000113263.1 NZ_CP009828:c2347911-2347645 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T49906 NZ_CP009828:c2347911-2347645 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGTTATTATAGTAGACGTATCAATCACGAACATAGATTGGTCTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT49906 WP_000584499.1 NZ_CP009828:c2348162-2347911 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT49906 NZ_CP009828:c2348162-2347911 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGAAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References