Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1608520..1608934 Replicon chromosome
Accession NZ_CP009828
Organism Staphylococcus aureus strain MS4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NI36_RS07850 Protein ID WP_001065099.1
Coordinates 1608683..1608934 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NI36_RS14580 Protein ID WP_000028424.1
Coordinates 1608520..1608693 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NI36_RS07795 1604302..1604646 - 345 WP_000402904.1 hypothetical protein -
NI36_RS07800 1604777..1605076 - 300 WP_000988330.1 HNH endonuclease -
NI36_RS07805 1605308..1605724 - 417 WP_000590122.1 hypothetical protein -
NI36_RS07810 1605752..1605952 - 201 WP_000265043.1 DUF1514 family protein -
NI36_RS07815 1605952..1606602 - 651 WP_001005262.1 hypothetical protein -
NI36_RS07820 1606761..1606910 - 150 WP_000237868.1 transcriptional activator RinB -
NI36_RS07825 1606913..1607113 - 201 WP_001125015.1 hypothetical protein -
NI36_RS07830 1607088..1607276 - 189 WP_000195782.1 DUF1381 domain-containing protein -
NI36_RS07835 1607273..1607518 - 246 WP_001282074.1 hypothetical protein -
NI36_RS07840 1607555..1608061 - 507 WP_001061834.1 dUTPase -
NI36_RS14575 1608076..1608237 - 162 WP_000889683.1 hypothetical protein -
NI36_RS07845 1608238..1608519 - 282 WP_000454994.1 hypothetical protein -
NI36_RS14580 1608520..1608693 - 174 WP_000028424.1 hypothetical protein Antitoxin
NI36_RS07850 1608683..1608934 - 252 WP_001065099.1 DUF1024 family protein Toxin
NI36_RS07855 1608949..1609191 - 243 WP_000131388.1 phi PVL orf 51-like protein -
NI36_RS07860 1609195..1609551 - 357 WP_000029366.1 hypothetical protein -
NI36_RS07865 1609552..1609737 - 186 WP_001187236.1 DUF3113 family protein -
NI36_RS07870 1609742..1610146 - 405 WP_000049798.1 DUF1064 domain-containing protein -
NI36_RS07875 1610156..1610377 - 222 WP_001123669.1 DUF3269 family protein -
NI36_RS07880 1610390..1610548 - 159 WP_000256594.1 hypothetical protein -
NI36_RS07885 1610542..1611321 - 780 WP_000803062.1 ATP-binding protein -
NI36_RS07890 1611331..1612101 - 771 WP_000190254.1 conserved phage C-terminal domain-containing protein -
NI36_RS07895 1612167..1612448 + 282 WP_000414755.1 hypothetical protein -
NI36_RS14585 1612441..1612590 - 150 WP_001081076.1 hypothetical protein -
NI36_RS07900 1612587..1613261 - 675 WP_000057262.1 hypothetical protein -
NI36_RS07905 1613273..1613716 - 444 WP_001099007.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukF-PV / lukS-PV / lukF-PV / lukS-PV 1536729..1640794 104065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9376.32 Da        Isoelectric Point: 3.8364

>T49901 WP_001065099.1 NZ_CP009828:c1608934-1608683 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T49901 NZ_CP009828:c1608934-1608683 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTAAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT49901 WP_000028424.1 NZ_CP009828:c1608693-1608520 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT49901 NZ_CP009828:c1608693-1608520 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References