Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1566348..1566762 Replicon chromosome
Accession NZ_CP009828
Organism Staphylococcus aureus strain MS4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NI36_RS07520 Protein ID WP_001065099.1
Coordinates 1566511..1566762 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NI36_RS14550 Protein ID WP_000028424.1
Coordinates 1566348..1566521 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NI36_RS07465 1562130..1562474 - 345 WP_000402904.1 hypothetical protein -
NI36_RS07470 1562605..1562904 - 300 WP_000988330.1 HNH endonuclease -
NI36_RS07475 1563136..1563552 - 417 WP_000590122.1 hypothetical protein -
NI36_RS07480 1563580..1563780 - 201 WP_000265043.1 DUF1514 family protein -
NI36_RS07485 1563780..1564430 - 651 WP_001005262.1 hypothetical protein -
NI36_RS07490 1564589..1564738 - 150 WP_000237868.1 transcriptional activator RinB -
NI36_RS07495 1564741..1564941 - 201 WP_001125015.1 hypothetical protein -
NI36_RS07500 1564916..1565104 - 189 WP_000195782.1 DUF1381 domain-containing protein -
NI36_RS07505 1565101..1565346 - 246 WP_001282074.1 hypothetical protein -
NI36_RS07510 1565383..1565889 - 507 WP_001061834.1 dUTPase -
NI36_RS14545 1565904..1566065 - 162 WP_000889683.1 hypothetical protein -
NI36_RS07515 1566066..1566347 - 282 WP_000454994.1 hypothetical protein -
NI36_RS14550 1566348..1566521 - 174 WP_000028424.1 hypothetical protein Antitoxin
NI36_RS07520 1566511..1566762 - 252 WP_001065099.1 DUF1024 family protein Toxin
NI36_RS07525 1566777..1567019 - 243 WP_000131388.1 phi PVL orf 51-like protein -
NI36_RS07530 1567023..1567379 - 357 WP_000029366.1 hypothetical protein -
NI36_RS07535 1567380..1567565 - 186 WP_001187236.1 DUF3113 family protein -
NI36_RS07540 1567570..1567974 - 405 WP_000049798.1 DUF1064 domain-containing protein -
NI36_RS07545 1567984..1568205 - 222 WP_001123669.1 DUF3269 family protein -
NI36_RS07550 1568218..1568376 - 159 WP_000256594.1 hypothetical protein -
NI36_RS07555 1568370..1569149 - 780 WP_000803062.1 ATP-binding protein -
NI36_RS07560 1569159..1569929 - 771 WP_000190254.1 conserved phage C-terminal domain-containing protein -
NI36_RS07565 1569995..1570276 + 282 WP_000414755.1 hypothetical protein -
NI36_RS14555 1570269..1570418 - 150 WP_001081076.1 hypothetical protein -
NI36_RS07570 1570415..1571089 - 675 WP_000057262.1 hypothetical protein -
NI36_RS07575 1571101..1571544 - 444 WP_001099007.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukF-PV / lukS-PV / lukF-PV / lukS-PV 1536729..1640794 104065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9376.32 Da        Isoelectric Point: 3.8364

>T49900 WP_001065099.1 NZ_CP009828:c1566762-1566511 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T49900 NZ_CP009828:c1566762-1566511 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTAAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT49900 WP_000028424.1 NZ_CP009828:c1566521-1566348 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT49900 NZ_CP009828:c1566521-1566348 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References