Detailed information of TA system TA049882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2483634..2484237
• Replicon: chromosome
• Accession: NZ_CP009823
• Organism: Xylella fastidiosa strain J1a12

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: OY18_RS12295
• Protein ID: WP_010893245.1
• Coordinates: 2483634..2483951 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: OY18_RS12300
• Protein ID: WP_010893244.1
• Coordinates: 2483962..2484237 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OY18_RS12270 (OY18_11535)	2478838..2480016	-	1179	WP_060871908.1	phage tail sheath family protein	-
OY18_RS12275 (OY18_11540)	2480081..2481673	-	1593	WP_060871907.1	tail fiber domain-containing protein	-
OY18_RS12280 (OY18_11545)	2481681..2482238	-	558	WP_060872396.1	phage tail protein I	-
OY18_RS12285 (OY18_11550)	2482231..2483124	-	894	WP_088569719.1	baseplate J/gp47 family protein	-
OY18_RS12290 (OY18_11555)	2483124..2483447	-	324	WP_228762820.1	GPW/gp25 family protein	-
OY18_RS12295 (OY18_11560)	2483634..2483951	+	318	WP_010893245.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OY18_RS12300 (OY18_11565)	2483962..2484237	+	276	WP_010893244.1	HigA family addiction module antitoxin	Antitoxin
OY18_RS12305 (OY18_11570)	2484242..2484829	-	588	WP_060871767.1	phage baseplate assembly protein V	-
OY18_RS12310 (OY18_11575)	2484826..2485368	-	543	WP_060872403.1	hypothetical protein	-
OY18_RS12315 (OY18_11580)	2485344..2485865	-	522	WP_010893241.1	hypothetical protein	-
OY18_RS12320 (OY18_11585)	2485862..2486185	-	324	WP_042462902.1	hypothetical protein	-
OY18_RS12325 (OY18_11590)	2486185..2486445	-	261	WP_060872391.1	hypothetical protein	-
OY18_RS12330 (OY18_11595)	2486463..2488343	-	1881	WP_088569720.1	phage major capsid protein	-
OY18_RS15260	2488327..2488866	-	540	Protein_2295	phage portal protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2473129..2515726	42597

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (15-105)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-88)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12076.78 Da
• Isoelectric Point: 9.6781

>T49882 WP_010893245.1 NZ_CP009823:2483634-2483951 [Xylella fastidiosa]
MYTDHLRYTIGFVIKSFRHKGIQQFFLEGSTAGIQTKHAAKLRIQLTALESAKHPKDMNAPGWKLHSLKGADLKGHWSIW
VNGNYRLTFAFEGEDAILVDYQDYH

Nucleotide

• Length: 318 bp

>T49882 NZ_CP009823:2483634-2483951 [Xylella fastidiosa]
ATGTATACCGATCATTTACGGTATACAATCGGCTTTGTGATCAAAAGTTTCCGCCACAAAGGCATTCAACAATTCTTCCT
CGAGGGATCAACCGCTGGTATCCAAACCAAACACGCCGCCAAACTGCGTATCCAGCTCACCGCGTTGGAGAGTGCTAAGC
ACCCCAAAGATATGAATGCTCCAGGCTGGAAACTGCACTCACTAAAAGGCGCTGACTTAAAAGGTCATTGGTCCATCTGG
GTAAATGGCAACTATCGCCTCACGTTTGCTTTTGAAGGCGAAGACGCAATCTTGGTCGACTATCAGGATTACCACTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10056.68 Da
• Isoelectric Point: 10.2184

>AT49882 WP_010893244.1 NZ_CP009823:2483962-2484237 [Xylella fastidiosa]
MKRMHNPAHPGEVLREYLGDLTVTNAAAKLGVSRVALSRILNGANGISADMALRLEDALGTSAEMWVAMQFKYDLWVASQ
QPRPKITRLHV

Nucleotide

• Length: 276 bp

>AT49882 NZ_CP009823:2483962-2484237 [Xylella fastidiosa]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGATCTCACTGTGACCAATGCGGC
TGCAAAGCTTGGCGTCAGCCGTGTCGCTTTGTCGCGTATTCTCAATGGTGCCAACGGCATCTCTGCCGATATGGCCCTAC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGTAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCCAGTCAG
CAGCCACGCCCGAAGATCACACGCCTTCATGTGTAA