Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3110644..3111320 Replicon chromosome
Accession NZ_CP009802
Organism Streptomyces sp. FR-008

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag SFR_RS13580 Protein ID WP_018471256.1
Coordinates 3110958..3111320 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SFR_RS13575 Protein ID WP_037844510.1
Coordinates 3110644..3110961 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFR_RS13550 3105940..3107001 + 1062 WP_030770447.1 hypothetical protein -
SFR_RS13555 3107207..3107737 + 531 WP_075986655.1 toxin-antitoxin system HicB family antitoxin -
SFR_RS13560 3107839..3108708 + 870 WP_075986656.1 DUF4097 family beta strand repeat protein -
SFR_RS13565 3108812..3109786 + 975 WP_003949891.1 daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein -
SFR_RS13570 3109783..3110565 + 783 WP_003949890.1 ABC transporter permease -
SFR_RS13575 3110644..3110961 - 318 WP_037844510.1 helix-turn-helix domain-containing protein Antitoxin
SFR_RS13580 3110958..3111320 - 363 WP_018471256.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SFR_RS13585 3111319..3113016 + 1698 WP_075986657.1 hypothetical protein -
SFR_RS13590 3113107..3113349 - 243 WP_030770433.1 hypothetical protein -
SFR_RS13595 3113653..3114507 + 855 WP_030770428.1 STAS domain-containing protein -
SFR_RS13600 3114504..3114884 + 381 WP_003949885.1 STAS domain-containing protein -
SFR_RS13605 3114884..3115300 + 417 WP_003949884.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13502.36 Da        Isoelectric Point: 4.6168

>T49872 WP_018471256.1 NZ_CP009802:c3111320-3110958 [Streptomyces sp. FR-008]
MDGEWQIFLVDEVRVWLASLDGAAHARVVQALDVLAEEGPALGRPLVDTLRGSAVANLKELRPGTVRILFAFDPWRSSIL
LVAGDKSGQWTEWYQEAIPLAEQRYALYLKEREREEGGRP

Download         Length: 363 bp

>T49872 NZ_CP009802:c3111320-3110958 [Streptomyces sp. FR-008]
ATGGACGGGGAATGGCAGATCTTCCTGGTTGACGAGGTGCGTGTTTGGCTCGCGTCCCTCGACGGGGCCGCGCACGCACG
AGTGGTGCAGGCGCTGGACGTGCTGGCCGAGGAAGGGCCTGCTCTCGGAAGACCGCTTGTGGACACCTTGCGTGGTTCAG
CGGTGGCCAATTTGAAAGAGCTCCGGCCCGGCACGGTCAGAATTCTGTTCGCCTTCGATCCGTGGCGTTCCAGCATCTTG
CTGGTGGCAGGTGACAAGTCCGGGCAGTGGACTGAGTGGTACCAGGAGGCGATCCCCCTGGCCGAGCAGCGCTACGCGCT
TTACTTGAAGGAACGTGAGCGGGAAGAGGGAGGACGACCATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11586.10 Da        Isoelectric Point: 9.8236

>AT49872 WP_037844510.1 NZ_CP009802:c3110961-3110644 [Streptomyces sp. FR-008]
MTSYTRWQDIRPEHVARAGGEEAVRAGKEELLAQVTGRKLAELRRARGLTQQEVADRMGVSKGRVSQIERGHLSGQEVLA
RFATALGGRLHQAIYFDDGDIVTIA

Download         Length: 318 bp

>AT49872 NZ_CP009802:c3110961-3110644 [Streptomyces sp. FR-008]
ATGACGAGTTACACCCGTTGGCAGGACATTCGTCCCGAGCATGTCGCCCGCGCAGGGGGTGAGGAAGCCGTACGCGCGGG
TAAGGAGGAGCTGCTCGCGCAGGTCACCGGGAGGAAGCTCGCGGAGCTGCGTCGCGCCCGAGGGCTGACCCAGCAGGAGG
TGGCGGACCGGATGGGGGTCAGCAAGGGGCGGGTCTCCCAGATCGAGCGGGGGCACCTTTCGGGACAGGAAGTGCTGGCC
CGATTCGCGACCGCTCTCGGAGGCCGTCTCCATCAGGCGATCTACTTCGACGACGGCGACATCGTCACCATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References