Detailed information of TA system TA049760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3061136..3061830
• Replicon: chromosome
• Accession: NZ_CP009786
• Organism: Yersinia pseudotuberculosis strain

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: BZ23_RS13925
• Protein ID: WP_024063131.1
• Coordinates: 3061534..3061830 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: BZ23_RS13920
• Protein ID: WP_002209924.1
• Coordinates: 3061136..3061534 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZ23_RS13885	3056244..3056609	+	366	WP_011192915.1	hypothetical protein	-
BZ23_RS23275	3056622..3057278	+	657	WP_024063133.1	hypothetical protein	-
BZ23_RS13900	3057460..3057660	+	201	WP_002209920.1	AlpA family transcriptional regulator	-
BZ23_RS23715	3057674..3057826	-	153	WP_002209921.1	hypothetical protein	-
BZ23_RS13910	3057819..3058145	-	327	WP_002209922.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BZ23_RS13915	3058445..3060736	+	2292	WP_024063132.1	toprim domain-containing protein	-
BZ23_RS13920	3061136..3061534	-	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BZ23_RS13925	3061534..3061830	-	297	WP_024063131.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BZ23_RS13930	3061994..3062356	-	363	WP_011192920.1	helix-turn-helix domain-containing protein	-
BZ23_RS13935	3062419..3062679	-	261	WP_002214785.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BZ23_RS13945	3063277..3063462	+	186	WP_002209928.1	hypothetical protein	-
BZ23_RS13950	3063544..3064758	-	1215	WP_011192954.1	tyrosine-type recombinase/integrase	-
BZ23_RS13960	3065191..3066708	-	1518	WP_002209930.1	lysine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3043206..3069728	26522

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11318.17 Da
• Isoelectric Point: 7.8810

>T49760 WP_024063131.1 NZ_CP009786:c3061830-3061534 [Yersinia pseudotuberculosis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEI

Nucleotide

• Length: 297 bp

>T49760 NZ_CP009786:c3061830-3061534 [Yersinia pseudotuberculosis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT49760 WP_002209924.1 NZ_CP009786:c3061534-3061136 [Yersinia pseudotuberculosis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT49760 NZ_CP009786:c3061534-3061136 [Yersinia pseudotuberculosis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Antitoxin

• AlphaFold DB: Q666X1