Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 6322087..6322601 Replicon chromosome
Accession NZ_CP009754
Organism Streptomyces sp. CCM_MD2014

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0N6ZQN6
Locus tag NI25_RS28090 Protein ID WP_061445117.1
Coordinates 6322087..6322341 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0N6ZSL8
Locus tag NI25_RS28095 Protein ID WP_061445118.1
Coordinates 6322338..6322601 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NI25_RS28065 6317285..6318553 + 1269 WP_061445112.1 site-specific integrase -
NI25_RS28070 6318629..6319990 - 1362 WP_061445113.1 type I glutamate--ammonia ligase -
NI25_RS28075 6320281..6320955 + 675 WP_061445114.1 DUF3105 domain-containing protein -
NI25_RS28080 6320952..6321578 + 627 WP_061445115.1 DUF305 domain-containing protein -
NI25_RS28085 6321607..6322053 - 447 WP_061445116.1 VOC family protein -
NI25_RS28090 6322087..6322341 - 255 WP_061445117.1 Txe/YoeB family addiction module toxin Toxin
NI25_RS28095 6322338..6322601 - 264 WP_061445118.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NI25_RS28100 6322776..6325787 + 3012 WP_061445119.1 bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase -
NI25_RS28105 6325816..6326739 - 924 WP_107072123.1 phosphatase PAP2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9969.31 Da        Isoelectric Point: 9.7377

>T49594 WP_061445117.1 NZ_CP009754:c6322341-6322087 [Streptomyces sp. CCM_MD2014]
VRITFTSHGWEDYVHWAESDRKVTKRINRLISDITRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPADDVLIIVQA
RYHY

Download         Length: 255 bp

>T49594 NZ_CP009754:c6322341-6322087 [Streptomyces sp. CCM_MD2014]
GTGAGGATCACTTTCACGTCCCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGGTGACCAAGCGGAT
CAACAGACTGATCAGCGACATCACCCGTGACCCGTTCAAGGGCATCGGCAAGCCGGAGCCGCTCAAGGGCGACCTGTCGG
GCTACTGGTCACGGCGCATCGACGACACGCACCGTCTTGTGTACAAACCCGCCGACGACGTCCTGATCATCGTCCAGGCG
CGCTACCACTACTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9794.87 Da        Isoelectric Point: 4.5670

>AT49594 WP_061445118.1 NZ_CP009754:c6322601-6322338 [Streptomyces sp. CCM_MD2014]
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPRNARRLLDSIAEAEAGEARERELI
DPDAERA

Download         Length: 264 bp

>AT49594 NZ_CP009754:c6322601-6322338 [Streptomyces sp. CCM_MD2014]
ATGTCCATCACCGCCAGCGAAGCCCGTCAGAACCTGTTCCCGCTGATAGAGCAGGTCAACGAGGACCATGCGCCGGTGCA
CATCACCTCCCGCAAGGGGAACGCCGTGCTCATGTCCGAGGAGGACTTCACGGCGTGGACGGAAACGGTGCATCTCCTGC
GCTCGCCGCGGAACGCCCGGCGCCTGCTCGACTCCATCGCGGAGGCCGAGGCGGGCGAGGCCCGGGAGCGCGAGTTGATC
GACCCGGACGCGGAGCGGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N6ZQN6

Antitoxin

Source ID Structure
AlphaFold DB A0A0N6ZSL8

References