Detailed information of TA system TA049584

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): bsrG-as-bsrG/-
• Location: 2189954..2190204
• Replicon: chromosome
• Accession: NZ_CP009748
• Organism: Bacillus subtilis strain ATCC 13952

Toxin (Protein)

• Gene name: bsrG
• Uniprot ID: L8EAY0
• Locus tag: KS08_RS20355
• Protein ID: WP_009967548.1
• Coordinates: 2189954..2190070 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	as-bsrG
Locus tag	-
Coordinates	2190065..2190204 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KS08_RS10870	2185091..2185351	+	261	WP_014472510.1	hypothetical protein	-
KS08_RS10875	2185503..2186665	+	1163	Protein_2142	tetratricopeptide repeat protein	-
KS08_RS10880	2186829..2188079	-	1251	WP_014470073.1	UV-damage repair protein uvrX	-
KS08_RS10885	2188072..2188404	-	333	WP_014470072.1	YolD-like family protein	-
KS08_RS10890	2188623..2189287	-	665	Protein_2145	sporulation protein YunB	-
KS08_RS10895	2189522..2189725	-	204	WP_014470071.1	hypothetical protein	-
KS08_RS20355	2189954..2190070	+	117	WP_009967548.1	type I toxin-antitoxin system toxin BsrG	Toxin
-	2190065..2190204	-	140	NuclAT_0	-	Antitoxin
-	2190065..2190204	-	140	NuclAT_0	-	Antitoxin
-	2190065..2190204	-	140	NuclAT_0	-	Antitoxin
-	2190065..2190204	-	140	NuclAT_0	-	Antitoxin
KS08_RS10900	2190378..2190836	-	459	WP_014470070.1	SMI1/KNR4 family protein	-
KS08_RS10905	2190849..2192735	-	1887	WP_014470069.1	HNH endonuclease	-
KS08_RS10910	2193242..2194012	+	771	WP_014470068.1	hypothetical protein	-
KS08_RS10915	2194056..2194490	-	435	WP_076982859.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2049155..2197526	148371

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-38)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4336.39 Da
• Isoelectric Point: 10.1022

>T49584 WP_009967548.1 NZ_CP009748:2189954-2190070 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Nucleotide

• Length: 117 bp

>T49584 NZ_CP009748:2189954-2190070 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin

Nucleotide

• Length: 140 bp

>AT49584 NZ_CP009748:c2190204-2190065 [Bacillus subtilis]
AAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCACCCCGGCTCTGTACAAAAAGCTGCCCATCAAAGGGCTTGCTCG
ATGTTGAATCTGCGTAGACCTAACCCTTTAAGGTTCCTAAGCTCAAGGGAAGGTCTATTT

Structures

Toxin

• AlphaFold DB: A0A7Z7EVU9

Antitoxin