Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2968745..2969439 Replicon chromosome
Accession NZ_CP009723
Organism Yersinia pestis strain Shasta

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag BZ15_RS14785 Protein ID WP_002214787.1
Coordinates 2968745..2969041 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag BZ15_RS14790 Protein ID WP_002209924.1
Coordinates 2969041..2969439 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ15_RS14750 2963867..2965384 + 1518 WP_002209930.1 lysine--tRNA ligase -
BZ15_RS14760 2965817..2967031 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
BZ15_RS14765 2967113..2967298 - 186 WP_002209928.1 hypothetical protein -
BZ15_RS14775 2967896..2968156 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
BZ15_RS14780 2968219..2968581 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
BZ15_RS14785 2968745..2969041 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
BZ15_RS14790 2969041..2969439 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
BZ15_RS14795 2969839..2972130 - 2292 WP_002209923.1 toprim domain-containing protein -
BZ15_RS14800 2972430..2972756 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
BZ15_RS25430 2972749..2972901 + 153 WP_002209921.1 hypothetical protein -
BZ15_RS14810 2972915..2973115 - 201 WP_002209920.1 AlpA family transcriptional regulator -
BZ15_RS14815 2973297..2973629 - 333 WP_002214791.1 hypothetical protein -
BZ15_RS14820 2973635..2973871 - 237 WP_002214792.1 hypothetical protein -
BZ15_RS14825 2973884..2974249 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T49545 WP_002214787.1 NZ_CP009723:2968745-2969041 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T49545 NZ_CP009723:2968745-2969041 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT49545 WP_002209924.1 NZ_CP009723:2969041-2969439 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT49545 NZ_CP009723:2969041-2969439 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References