Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 3953186..3953880 | Replicon | chromosome |
| Accession | NZ_CP009712 | ||
| Organism | Yersinia pseudotuberculosis IP 32953 strain IP32953 | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | - |
| Locus tag | BZ17_RS18340 | Protein ID | WP_024063131.1 |
| Coordinates | 3953186..3953482 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | Q666X1 |
| Locus tag | BZ17_RS18345 | Protein ID | WP_002209924.1 |
| Coordinates | 3953482..3953880 (+) | Length | 133 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BZ17_RS18290 | 3948359..3948628 | - | 270 | WP_011192925.1 | hypothetical protein | - |
| BZ17_RS18295 | 3948775..3949008 | + | 234 | WP_041175468.1 | hypothetical protein | - |
| BZ17_RS18300 | 3949187..3949471 | - | 285 | WP_011192924.1 | hypothetical protein | - |
| BZ17_RS18305 | 3949468..3949680 | - | 213 | WP_012413891.1 | hypothetical protein | - |
| BZ17_RS18310 | 3949677..3949949 | - | 273 | WP_011192923.1 | hypothetical protein | - |
| BZ17_RS23165 | 3950063..3950362 | + | 300 | WP_012413890.1 | helix-turn-helix domain-containing protein | - |
| BZ17_RS18315 | 3950429..3951412 | + | 984 | WP_011192921.1 | tyrosine-type recombinase/integrase | - |
| BZ17_RS18320 | 3951554..3951739 | - | 186 | WP_002209928.1 | hypothetical protein | - |
| BZ17_RS18330 | 3952337..3952597 | + | 261 | WP_002214785.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BZ17_RS18335 | 3952660..3953022 | + | 363 | WP_011192920.1 | helix-turn-helix domain-containing protein | - |
| BZ17_RS18340 | 3953186..3953482 | + | 297 | WP_024063131.1 | type II toxin-antitoxin system MqsR family toxin | Toxin |
| BZ17_RS18345 | 3953482..3953880 | + | 399 | WP_002209924.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
| BZ17_RS18350 | 3954280..3956571 | - | 2292 | WP_011192918.1 | toprim domain-containing protein | - |
| BZ17_RS18355 | 3956871..3957197 | + | 327 | WP_011192917.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BZ17_RS24440 | 3957190..3957342 | + | 153 | WP_002209921.1 | hypothetical protein | - |
| BZ17_RS18365 | 3957356..3957556 | - | 201 | WP_002209920.1 | AlpA family transcriptional regulator | - |
| BZ17_RS24075 | 3957738..3958394 | - | 657 | WP_011192916.1 | hypothetical protein | - |
| BZ17_RS18380 | 3958407..3958772 | - | 366 | WP_011192915.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3945746..3971826 | 26080 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11318.17 Da Isoelectric Point: 7.8810
>T49515 WP_024063131.1 NZ_CP009712:3953186-3953482 [Yersinia pseudotuberculosis IP 32953]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEI
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEI
Download Length: 297 bp
>T49515 NZ_CP009712:3953186-3953482 [Yersinia pseudotuberculosis IP 32953]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGATTTAA
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGATTTAA
Antitoxin
Download Length: 133 a.a. Molecular weight: 14657.17 Da Isoelectric Point: 8.4923
>AT49515 WP_002209924.1 NZ_CP009712:3953482-3953880 [Yersinia pseudotuberculosis IP 32953]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR
Download Length: 399 bp
>AT49515 NZ_CP009712:3953482-3953880 [Yersinia pseudotuberculosis IP 32953]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|