Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 654844..655342 Replicon chromosome
Accession NZ_CP009706
Organism Hafnia alvei FB1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A097QY90
Locus tag AT03_RS03030 Protein ID WP_025798702.1
Coordinates 654844..655098 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A097QYE6
Locus tag AT03_RS03035 Protein ID WP_025798704.1
Coordinates 655091..655342 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT03_RS03000 650458..650991 + 534 WP_025798691.1 SprT family zinc-dependent metalloprotease -
AT03_RS03005 651121..651831 + 711 WP_025798693.1 deoxyribonuclease I -
AT03_RS03010 651954..652685 + 732 WP_025798695.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
AT03_RS03015 652695..653648 + 954 WP_025798697.1 glutathione synthase -
AT03_RS03020 653853..654416 + 564 WP_025798698.1 YqgE/AlgH family protein -
AT03_RS03025 654416..654838 + 423 WP_025798700.1 Holliday junction resolvase RuvX -
AT03_RS03030 654844..655098 - 255 WP_025798702.1 Txe/YoeB family addiction module toxin Toxin
AT03_RS03035 655091..655342 - 252 WP_025798704.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AT03_RS03040 655407..656423 - 1017 WP_025798706.1 type IV pilus twitching motility protein PilT -
AT03_RS03045 656446..657159 + 714 WP_025798708.1 YggS family pyridoxal phosphate-dependent enzyme -
AT03_RS03050 657233..657787 + 555 WP_025798710.1 YggT family protein -
AT03_RS03055 657793..658095 + 303 WP_025798712.1 YggU family protein -
AT03_RS03060 658149..658742 + 594 WP_025798714.1 RdgB/HAM1 family non-canonical purine NTP pyrophosphatase -
AT03_RS03065 658735..659865 + 1131 WP_025798716.1 radical SAM family heme chaperone HemW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10489.99 Da        Isoelectric Point: 8.8753

>T49483 WP_025798702.1 NZ_CP009706:c655098-654844 [Hafnia alvei FB1]
MNKFFTDESWADYVFWQENDKRFIKRINELIKEIERAPFTGIGKPEPLKHHLSGYWSRRINEEHRLIYRVEQDRMIILSC
RYHY

Download         Length: 255 bp

>T49483 NZ_CP009706:c655098-654844 [Hafnia alvei FB1]
ATGAATAAATTCTTCACGGATGAGTCTTGGGCCGATTATGTTTTCTGGCAGGAAAATGACAAACGTTTTATTAAACGTAT
CAATGAATTGATTAAAGAAATTGAAAGGGCCCCATTCACAGGAATTGGCAAACCAGAGCCTTTAAAACATCATCTATCGG
GTTATTGGTCACGCAGAATTAATGAAGAACACCGGCTCATTTATCGGGTAGAACAAGACAGGATGATCATCCTGTCTTGC
CGCTACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9183.54 Da        Isoelectric Point: 5.7782

>AT49483 WP_025798704.1 NZ_CP009706:c655342-655091 [Hafnia alvei FB1]
MRNITYSAARATLASVMDQTIQDCTPILITRQNGEDCVLMSSKEYSSLMETAYLMRSPSNAEHLLKSLAQASAKALEKKV
LDE

Download         Length: 252 bp

>AT49483 NZ_CP009706:c655342-655091 [Hafnia alvei FB1]
ATGCGTAATATCACCTACTCAGCGGCTCGAGCCACTTTAGCCTCAGTCATGGATCAAACGATTCAGGACTGCACGCCCAT
ACTTATCACCCGTCAAAATGGTGAAGACTGCGTTTTAATGTCTAGCAAAGAGTATTCCAGCCTCATGGAAACCGCTTATT
TAATGCGCTCGCCCTCGAATGCTGAACACCTGCTTAAATCATTGGCACAAGCTAGCGCCAAGGCTCTAGAAAAGAAGGTG
CTGGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QY90

Antitoxin

Source ID Structure
AlphaFold DB A0A097QYE6

References