Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 645887..646150 Replicon chromosome
Accession NZ_CP009706
Organism Hafnia alvei FB1

Toxin (Protein)


Gene name hokH Uniprot ID A0A1C6YY26
Locus tag AT03_RS21690 Protein ID WP_025798685.1
Coordinates 645992..646150 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name sokH
Locus tag -
Coordinates 645887..645944 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT03_RS02970 641089..642159 - 1071 WP_025798678.1 dihydroxyacetone kinase subunit DhaK -
AT03_RS02975 642265..643365 - 1101 WP_025798680.1 glycerol dehydrogenase -
AT03_RS02980 643878..644561 + 684 WP_025798682.1 DUF1190 family protein -
AT03_RS02985 644564..645724 + 1161 WP_025798684.1 glutathionylspermidine synthase family protein -
- 645887..645944 - 58 - - Antitoxin
AT03_RS21690 645992..646150 + 159 WP_025798685.1 Hok/Gef family protein Toxin
AT03_RS02990 646311..648530 - 2220 WP_025798687.1 lysine decarboxylase -
AT03_RS02995 648636..649964 - 1329 WP_025798689.1 cadaverine/lysine antiporter -
AT03_RS03000 650458..650991 + 534 WP_025798691.1 SprT family zinc-dependent metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-46)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6065.37 Da        Isoelectric Point: 9.2226

>T49480 WP_025798685.1 NZ_CP009706:645992-646150 [Hafnia alvei FB1]
MSRKLLLYGLIVMCFTLLIFTWMVRGSLCELRIKQGKTEVAAFLNYEDKHAL

Download         Length: 159 bp

>T49480 NZ_CP009706:645992-646150 [Hafnia alvei FB1]
ATGTCGCGTAAGCTGTTGCTTTACGGATTAATAGTGATGTGTTTTACGCTATTGATCTTTACCTGGATGGTACGTGGTTC
GCTGTGTGAGCTACGAATTAAGCAGGGAAAAACAGAGGTTGCCGCGTTCTTAAACTACGAAGATAAGCACGCGTTGTAA

Antitoxin


Download         Length: 58 bp

>AT49480 NZ_CP009706:c645944-645887 [Hafnia alvei FB1]
GTTCAGATGTGGTTAGGATTGCCTCAGGTTAATGTAAGTTGACCTGGGGCTTTTACTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C6YY26

Antitoxin

Download structure file

References