Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2414763..2415042 Replicon chromosome
Accession NZ_CP009681
Organism Staphylococcus aureus strain Gv69

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SAGV69_RS12630 Protein ID WP_001802298.1
Coordinates 2414938..2415042 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2414763..2414942 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAGV69_RS12610 2410962..2411627 - 666 WP_001024094.1 SDR family oxidoreductase -
SAGV69_RS12615 2411779..2412099 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
SAGV69_RS12620 2412101..2413081 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
SAGV69_RS12625 2413347..2414438 + 1092 WP_000495671.1 lytic regulatory protein -
- 2414763..2414942 + 180 - - Antitoxin
SAGV69_RS12630 2414938..2415042 - 105 WP_001802298.1 hypothetical protein Toxin
SAGV69_RS17070 2415203..2415686 - 484 Protein_2407 recombinase family protein -
SAGV69_RS12640 2415729..2416865 - 1137 WP_000115564.1 SAP domain-containing protein -
SAGV69_RS12645 2417154..2417246 + 93 WP_001790138.1 hypothetical protein -
SAGV69_RS12650 2417951..2418808 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
SAGV69_RS12655 2418876..2419658 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T49419 WP_001802298.1 NZ_CP009681:c2415042-2414938 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T49419 NZ_CP009681:c2415042-2414938 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 180 bp

>AT49419 NZ_CP009681:2414763-2414942 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References