Detailed information of TA system TA049419

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2414763..2415042
• Replicon: chromosome
• Accession: NZ_CP009681
• Organism: Staphylococcus aureus strain Gv69

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: SAGV69_RS12630
• Protein ID: WP_001802298.1
• Coordinates: 2414938..2415042 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2414763..2414942 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV69_RS12610	2410962..2411627	-	666	WP_001024094.1	SDR family oxidoreductase	-
SAGV69_RS12615	2411779..2412099	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
SAGV69_RS12620	2412101..2413081	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
SAGV69_RS12625	2413347..2414438	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2414763..2414942	+	180	-	-	Antitoxin
SAGV69_RS12630	2414938..2415042	-	105	WP_001802298.1	hypothetical protein	Toxin
SAGV69_RS17070	2415203..2415686	-	484	Protein_2407	recombinase family protein	-
SAGV69_RS12640	2415729..2416865	-	1137	WP_000115564.1	SAP domain-containing protein	-
SAGV69_RS12645	2417154..2417246	+	93	WP_001790138.1	hypothetical protein	-
SAGV69_RS12650	2417951..2418808	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
SAGV69_RS12655	2418876..2419658	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T49419 WP_001802298.1 NZ_CP009681:c2415042-2414938 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T49419 NZ_CP009681:c2415042-2414938 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT49419 NZ_CP009681:2414763-2414942 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin