Detailed information of TA system TA049413

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2233625..2233924
• Replicon: chromosome
• Accession: NZ_CP009681
• Organism: Staphylococcus aureus strain Gv69

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAGV69_RS16620
• Protein ID: WP_011447039.1
• Coordinates: 2233748..2233924 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2233625..2233680 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV69_RS11535	2229324..2229422	-	99	WP_001803958.1	hypothetical protein	-
SAGV69_RS11540	2229518..2230732	+	1215	WP_000286469.1	NADH-dependent flavin oxidoreductase	-
SAGV69_RS11545	2230790..2231617	+	828	WP_000136022.1	alpha/beta hydrolase	-
SAGV69_RS11550	2232515..2233270	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAGV69_RS11555	2233282..2233536	-	255	WP_000611512.1	phage holin	-
SAGV69_RS11560	2233588..2233695	+	108	WP_001791821.1	hypothetical protein	-
-	2233617..2233756	+	140	NuclAT_0	-	-
-	2233617..2233756	+	140	NuclAT_0	-	-
-	2233617..2233756	+	140	NuclAT_0	-	-
-	2233617..2233756	+	140	NuclAT_0	-	-
-	2233625..2233680	+	56	-	-	Antitoxin
SAGV69_RS16620	2233748..2233924	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAGV69_RS11570	2234074..2234370	-	297	WP_042857037.1	DUF2951 domain-containing protein	-
SAGV69_RS17065	2234428..2234715	-	288	Protein_2207	hypothetical protein	-
SAGV69_RS11580	2234762..2234915	-	154	Protein_2208	hypothetical protein	-
SAGV69_RS16625	2234905..2238693	-	3789	Protein_2209	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M) / aph(3')-III / ant(6)-Ia	hlb	2117877..2271690	153813

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T49413 WP_011447039.1 NZ_CP009681:c2233924-2233748 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T49413 NZ_CP009681:c2233924-2233748 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGGTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT49413 NZ_CP009681:2233625-2233680 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin