Detailed information of TA system TA049409

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 919731..920310
• Replicon: chromosome
• Accession: NZ_CP009681
• Organism: Staphylococcus aureus strain Gv69

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SAGV69_RS04805
• Protein ID: WP_001025401.1
• Coordinates: 919731..919976 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	919945..920310 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV69_RS16970	915684..916299	+	616	Protein_897	ATPase	-
SAGV69_RS04765	916296..916442	-	147	WP_001013104.1	hypothetical protein	-
SAGV69_RS04770	916672..917256	-	585	WP_000825948.1	hypothetical protein	-
SAGV69_RS04775	917274..917735	-	462	WP_000525004.1	hypothetical protein	-
SAGV69_RS04780	917748..918077	-	330	WP_001573842.1	helix-turn-helix domain-containing protein	-
SAGV69_RS04785	918269..918514	+	246	WP_001573844.1	helix-turn-helix domain-containing protein	-
SAGV69_RS04790	918528..919304	+	777	WP_031886646.1	Rha family transcriptional regulator	-
SAGV69_RS04795	919333..919476	+	144	WP_000939498.1	hypothetical protein	-
SAGV69_RS04800	919466..919675	-	210	WP_000642492.1	hypothetical protein	-
SAGV69_RS04805	919731..919976	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SAGV69_RS04810	919945..920310	-	366	WP_001128433.1	hypothetical protein	Antitoxin
SAGV69_RS04815	920365..920580	+	216	WP_001097552.1	hypothetical protein	-
SAGV69_RS04820	920605..920868	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
SAGV69_RS04825	920881..921042	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
SAGV69_RS04830	921121..921444	+	324	WP_000175001.1	hypothetical protein	-
SAGV69_RS04835	921459..921821	+	363	WP_000985984.1	hypothetical protein	-
SAGV69_RS04840	921818..922984	+	1167	WP_000762547.1	DUF2800 domain-containing protein	-
SAGV69_RS04845	923010..923567	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T49409 WP_001025401.1 NZ_CP009681:919731-919976 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T49409 NZ_CP009681:919731-919976 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT49409 NZ_CP009681:c920310-919945 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin