Detailed information of TA system TA049402

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 413617..413956
• Replicon: chromosome
• Accession: NZ_CP009681
• Organism: Staphylococcus aureus strain Gv69

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAGV69_RS16040
• Protein ID: WP_011447039.1
• Coordinates: 413617..413793 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	413781..413956 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV69_RS02000	408852..412637	+	3786	WP_042857036.1	phage minor structural protein	-
SAGV69_RS02005	412627..412779	+	153	WP_001153681.1	hypothetical protein	-
SAGV69_RS02010	412826..413113	+	288	WP_001040261.1	hypothetical protein	-
SAGV69_RS02015	413171..413467	+	297	WP_042857037.1	DUF2951 domain-containing protein	-
SAGV69_RS16040	413617..413793	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	413781..413956	-	176	-	-	Antitoxin
SAGV69_RS02025	414006..414260	+	255	WP_000611512.1	phage holin	-
SAGV69_RS02030	414272..415027	+	756	WP_000861038.1	CHAP domain-containing protein	-
SAGV69_RS02035	415218..415709	+	492	WP_000919350.1	staphylokinase	-
SAGV69_RS16895	416359..416694	+	336	Protein_406	SH3 domain-containing protein	-
SAGV69_RS02045	416789..417238	-	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
SAGV69_RS02050	417919..418269	+	351	WP_000702262.1	complement inhibitor SCIN-A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	374387..419980	45593
	-	flank	IS/Tn	-	-	418376..419980	1604

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T49402 WP_011447039.1 NZ_CP009681:413617-413793 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T49402 NZ_CP009681:413617-413793 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGGTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 176 bp

>AT49402 NZ_CP009681:c413956-413781 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGTAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCC
CGTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGA
TGGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin