Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 673872..674541 Replicon chromosome
Accession NZ_CP009610
Organism Haemophilus influenzae strain Hi375

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag NF38_RS03415 Protein ID WP_015701504.1
Coordinates 673872..674255 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag NF38_RS03420 Protein ID WP_005651224.1
Coordinates 674239..674541 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF38_RS03380 670632..670955 + 324 WP_038440695.1 DUF2190 family protein -
NF38_RS03385 670936..671247 + 312 WP_015701509.1 hypothetical protein -
NF38_RS03390 671250..671780 + 531 WP_015701508.1 phage tail protein -
NF38_RS03395 671789..672199 + 411 WP_038440699.1 phage tail protein -
NF38_RS03400 672202..672852 + 651 WP_038440702.1 hypothetical protein -
NF38_RS03405 673127..673534 + 408 WP_038440705.1 hypothetical protein -
NF38_RS03410 673579..673803 + 225 WP_038440708.1 DUF4035 domain-containing protein -
NF38_RS03415 673872..674255 + 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NF38_RS03420 674239..674541 + 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
NF38_RS03425 674557..674793 + 237 WP_101494098.1 hypothetical protein -
NF38_RS03430 674845..677985 + 3141 WP_038440711.1 phage tail tape measure protein -
NF38_RS03435 677994..678326 + 333 WP_038440713.1 phage tail protein -
NF38_RS09400 678653..678811 + 159 WP_005651234.1 hypothetical protein -
NF38_RS03440 679071..679448 + 378 WP_005643783.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 642241..689772 47531


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T49322 WP_015701504.1 NZ_CP009610:673872-674255 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

>T49322 NZ_CP009610:673872-674255 [Haemophilus influenzae]
ATGAAACAAGAATGGGAAGTAATTTTACAAGACCCACTTTTGAACTGGTTAGAAACGCTGGCAGAAGATGACGTATTAAA
AATCTATGCGGCGTTGGAATTATTATCAACAGAAGGTCCACAATTAAGCAGACCTTATGCGGATACGCTGCAAGGCTCTA
AATATACCAATTTAAAAGAATTGCGAGTACAGTCTAAATTATCGGTATTCCGTTTATTTTATATTTTCGACCCTGTCAGA
CAAGCGATTGTTTTATGTGGCGGAGATAAAAAAGGCAAGAAAGAAAAACTCTTTTACAAAGAGATGATTGCCCTAGCGGA
ACAAACCTATGATGATTACCTTTCTGAATTAACTAAGGAGCAAGAAAATGAGCGTGAAATTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT49322 WP_005651224.1 NZ_CP009610:674239-674541 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp

>AT49322 NZ_CP009610:674239-674541 [Haemophilus influenzae]
ATGAGCGTGAAATTTAAAGATCTGATGAATAATCTTCCAGCTGAAAAGCAAGCGAAAGTGAAAGCTATGGCAGACGATAT
GCGAATGGAGTTACAACTTTACCGTATTCGTGAAGAATTAGAGCTTTCACAAAAGCAAATGGCAGAAGCATTAAGTATTT
CTCAGCCGTCAGTTGTCGCCCTTGAAAAACGTGGCAATGACATTAAATTATCATCAGTTAAACGTTACATTGAAGCAATG
GGTGGTGTGTTAAATTTATCGGTTGAATTACCCACAGGAAAAACAGTTACTTTCAACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References