Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 74368..75025 | Replicon | plasmid pCVM21538 |
| Accession | NZ_CP009563 | ||
| Organism | Salmonella enterica subsp. enterica serovar Newport str. CVM 21538 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | SEEN538_RS00510 | Protein ID | WP_000270043.1 |
| Coordinates | 74675..75025 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | SEEN538_RS00505 | Protein ID | WP_000124640.1 |
| Coordinates | 74368..74670 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SEEN538_RS00455 | 69993..70421 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| SEEN538_RS00460 | 70478..70837 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| SEEN538_RS00465 | 70837..71283 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| SEEN538_RS00470 | 71280..71798 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| SEEN538_RS00475 | 71798..72028 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| SEEN538_RS00480 | 72015..72872 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| SEEN538_RS00490 | 73103..73630 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| SEEN538_RS00495 | 73688..73960 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| SEEN538_RS00500 | 74048..74341 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| SEEN538_RS00505 | 74368..74670 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| SEEN538_RS00510 | 74675..75025 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| SEEN538_RS00515 | 75188..75736 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| SEEN538_RS00525 | 76077..76271 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| SEEN538_RS00530 | 76282..76653 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| SEEN538_RS00535 | 76646..77116 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| SEEN538_RS00540 | 77131..77466 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| SEEN538_RS00545 | 77563..78051 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| SEEN538_RS00550 | 78054..78551 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| SEEN538_RS00555 | 78766..79470 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| SEEN538_RS00560 | 79535..79714 | - | 180 | Protein_103 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..80098 | 80098 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 17237.68 Da Isoelectric Point: 5.5500
>T49284 WP_000270043.1 NZ_CP009563:c75025-74675 [Salmonella enterica subsp. enterica serovar Newport str. CVM 21538]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 351 bp
>T49284 NZ_CP009563:c75025-74675 [Salmonella enterica subsp. enterica serovar Newport str. CVM 21538]
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Antitoxin
Download Length: 101 a.a. Molecular weight: 14882.85 Da Isoelectric Point: 5.5500
>AT49284 WP_000124640.1 NZ_CP009563:c74670-74368 [Salmonella enterica subsp. enterica serovar Newport str. CVM 21538]
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Download Length: 303 bp
>AT49284 NZ_CP009563:c74670-74368 [Salmonella enterica subsp. enterica serovar Newport str. CVM 21538]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|