Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 72118..72775 | Replicon | plasmid pCVM22513 |
| Accession | NZ_CP009562 | ||
| Organism | Salmonella enterica subsp. enterica serovar Newport str. CVM 22513 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | SEEN513_RS00420 | Protein ID | WP_000270043.1 |
| Coordinates | 72425..72775 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | SEEN513_RS00415 | Protein ID | WP_000124640.1 |
| Coordinates | 72118..72420 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SEEN513_RS00365 | 67743..68171 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| SEEN513_RS00370 | 68228..68587 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| SEEN513_RS00375 | 68587..69033 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| SEEN513_RS00380 | 69030..69548 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| SEEN513_RS00385 | 69548..69778 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| SEEN513_RS00390 | 69765..70622 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| SEEN513_RS00400 | 70853..71380 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| SEEN513_RS00405 | 71438..71710 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| SEEN513_RS00410 | 71798..72091 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| SEEN513_RS00415 | 72118..72420 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| SEEN513_RS00420 | 72425..72775 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| SEEN513_RS00425 | 72938..73486 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| SEEN513_RS00435 | 73827..74021 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| SEEN513_RS00440 | 74032..74403 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| SEEN513_RS00445 | 74396..74866 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| SEEN513_RS00450 | 74881..75216 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| SEEN513_RS00455 | 75313..75801 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| SEEN513_RS00460 | 75804..76301 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| SEEN513_RS00465 | 76516..77220 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| SEEN513_RS00470 | 77285..77464 | - | 180 | Protein_85 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..120346 | 120346 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 17237.68 Da Isoelectric Point: 5.5500
>T49283 WP_000270043.1 NZ_CP009562:c72775-72425 [Salmonella enterica subsp. enterica serovar Newport str. CVM 22513]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 351 bp
>T49283 NZ_CP009562:c72775-72425 [Salmonella enterica subsp. enterica serovar Newport str. CVM 22513]
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Antitoxin
Download Length: 101 a.a. Molecular weight: 14882.85 Da Isoelectric Point: 5.5500
>AT49283 WP_000124640.1 NZ_CP009562:c72420-72118 [Salmonella enterica subsp. enterica serovar Newport str. CVM 22513]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
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Download Length: 303 bp
>AT49283 NZ_CP009562:c72420-72118 [Salmonella enterica subsp. enterica serovar Newport str. CVM 22513]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|