Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 106884..107541 | Replicon | plasmid pCVM22425 |
| Accession | NZ_CP009560 | ||
| Organism | Salmonella enterica subsp. enterica serovar Newport str. CVM 22425 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | SEEN425_RS00635 | Protein ID | WP_000270043.1 |
| Coordinates | 107191..107541 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | SEEN425_RS00630 | Protein ID | WP_000124640.1 |
| Coordinates | 106884..107186 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SEEN425_RS00580 | 102509..102937 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| SEEN425_RS00585 | 102994..103353 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| SEEN425_RS00590 | 103353..103799 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| SEEN425_RS00595 | 103796..104314 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| SEEN425_RS00600 | 104314..104544 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| SEEN425_RS00605 | 104531..105388 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| SEEN425_RS00615 | 105619..106146 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| SEEN425_RS00620 | 106204..106476 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| SEEN425_RS00625 | 106564..106857 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| SEEN425_RS00630 | 106884..107186 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| SEEN425_RS00635 | 107191..107541 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| SEEN425_RS00640 | 107704..108252 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| SEEN425_RS00650 | 108593..108787 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| SEEN425_RS00655 | 108798..109169 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| SEEN425_RS00660 | 109162..109632 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| SEEN425_RS00665 | 109647..109982 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| SEEN425_RS00670 | 110079..110567 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| SEEN425_RS00675 | 110570..111067 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| SEEN425_RS00680 | 111282..111986 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| SEEN425_RS00685 | 112051..112230 | - | 180 | Protein_127 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..158195 | 158195 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 17237.68 Da Isoelectric Point: 5.5500
>T49282 WP_000270043.1 NZ_CP009560:c107541-107191 [Salmonella enterica subsp. enterica serovar Newport str. CVM 22425]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 351 bp
>T49282 NZ_CP009560:c107541-107191 [Salmonella enterica subsp. enterica serovar Newport str. CVM 22425]
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Antitoxin
Download Length: 101 a.a. Molecular weight: 14882.85 Da Isoelectric Point: 5.5500
>AT49282 WP_000124640.1 NZ_CP009560:c107186-106884 [Salmonella enterica subsp. enterica serovar Newport str. CVM 22425]
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Download Length: 303 bp
>AT49282 NZ_CP009560:c107186-106884 [Salmonella enterica subsp. enterica serovar Newport str. CVM 22425]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|