Detailed information of TA system TA049270

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2101362..2101669
• Replicon: chromosome
• Accession: NZ_CP009554
• Organism: Staphylococcus aureus strain FORC_001

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: FORC1_RS15190
• Protein ID: WP_078103063.1
• Coordinates: 2101493..2101669 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2101362..2101501 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC1_RS10420	2096400..2096650	+	251	Protein_1982	sphingomyelin phosphodiesterase	-
FORC1_RS10425	2096972..2097151	+	180	WP_000669789.1	hypothetical protein	-
FORC1_RS10435	2097462..2097722	+	261	WP_001791826.1	hypothetical protein	-
FORC1_RS10440	2097775..2098125	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
FORC1_RS15575	2098636..2098974	-	339	Protein_1986	SH3 domain-containing protein	-
FORC1_RS10450	2099578..2100069	-	492	WP_000920041.1	staphylokinase	-
FORC1_RS10455	2100260..2101015	-	756	WP_000861038.1	CHAP domain-containing protein	-
FORC1_RS10460	2101027..2101281	-	255	WP_000611512.1	phage holin	-
FORC1_RS10465	2101333..2101440	+	108	WP_001791821.1	hypothetical protein	-
-	2101362..2101501	+	140	NuclAT_0	-	Antitoxin
-	2101362..2101501	+	140	NuclAT_0	-	Antitoxin
-	2101362..2101501	+	140	NuclAT_0	-	Antitoxin
-	2101362..2101501	+	140	NuclAT_0	-	Antitoxin
FORC1_RS15190	2101493..2101669	-	177	WP_078103063.1	putative holin-like toxin	Toxin
FORC1_RS10475	2101778..2102551	-	774	WP_000750407.1	staphylococcal enterotoxin type A	-
FORC1_RS10480	2102972..2103346	-	375	WP_042363643.1	hypothetical protein	-
FORC1_RS10485	2103402..2103689	-	288	WP_001040259.1	hypothetical protein	-
FORC1_RS10490	2103736..2103888	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / tsst-1 / groEL	2097775..2164594	66819

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6873.43 Da
• Isoelectric Point: 10.6777

>T49270 WP_078103063.1 NZ_CP009554:c2101669-2101493 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALHKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T49270 NZ_CP009554:c2101669-2101493 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACATAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT49270 NZ_CP009554:2101362-2101501 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin