Detailed information of TA system TA049264

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1601937..1602516
• Replicon: chromosome
• Accession: NZ_CP009554
• Organism: Staphylococcus aureus strain FORC_001

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: FORC1_RS07780
• Protein ID: WP_001025401.1
• Coordinates: 1602271..1602516 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1601937..1602302 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC1_RS07740	1598680..1599237	-	558	WP_000645048.1	DUF2815 family protein	-
FORC1_RS07745	1599263..1600429	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
FORC1_RS07750	1600426..1600788	-	363	WP_000985972.1	hypothetical protein	-
FORC1_RS07755	1600803..1601126	-	324	WP_000174998.1	hypothetical protein	-
FORC1_RS07760	1601205..1601366	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
FORC1_RS07765	1601379..1601642	-	264	WP_001124157.1	helix-turn-helix domain-containing protein	-
FORC1_RS07770	1601667..1601882	-	216	WP_001097552.1	hypothetical protein	-
FORC1_RS07775	1601937..1602302	+	366	WP_001128433.1	hypothetical protein	Antitoxin
FORC1_RS07780	1602271..1602516	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
FORC1_RS07785	1602583..1602963	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
FORC1_RS07790	1602950..1603147	-	198	WP_001148860.1	hypothetical protein	-
FORC1_RS07795	1603217..1603429	+	213	WP_000362644.1	hypothetical protein	-
FORC1_RS15695	1603470..1603619	-	150	WP_000771849.1	hypothetical protein	-
FORC1_RS07800	1603634..1604077	-	444	WP_000435360.1	hypothetical protein	-
FORC1_RS07805	1604125..1604337	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
FORC1_RS07810	1604489..1605220	+	732	WP_000511090.1	XRE family transcriptional regulator	-
FORC1_RS07815	1605291..1605473	+	183	WP_000705240.1	hypothetical protein	-
FORC1_RS07820	1605510..1605656	+	147	WP_001013104.1	hypothetical protein	-
FORC1_RS07825	1605653..1606267	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1563460..1620372	56912

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T49264 WP_001025401.1 NZ_CP009554:c1602516-1602271 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T49264 NZ_CP009554:c1602516-1602271 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT49264 NZ_CP009554:1601937-1602302 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin