Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1594906..1595329 Replicon chromosome
Accession NZ_CP009554
Organism Staphylococcus aureus strain FORC_001

Toxin (Protein)


Gene name higB Uniprot ID A0A6B5KJM6
Locus tag FORC1_RS07705 Protein ID WP_001065110.1
Coordinates 1595078..1595329 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E1X568
Locus tag FORC1_RS07700 Protein ID WP_000028425.1
Coordinates 1594906..1595088 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC1_RS07660 1590299..1590589 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
FORC1_RS07665 1590723..1590827 + 105 WP_015978074.1 hypothetical protein -
FORC1_RS07670 1590930..1593377 - 2448 WP_000884879.1 virulence-associated E family protein -
FORC1_RS07675 1593430..1593630 - 201 WP_000265258.1 DUF1514 family protein -
FORC1_RS07680 1593698..1593850 - 153 WP_000595237.1 transcriptional activator RinB -
FORC1_RS07685 1593843..1594079 - 237 WP_000483477.1 hypothetical protein -
FORC1_RS07690 1594104..1594340 - 237 WP_000195806.1 DUF1381 domain-containing protein -
FORC1_RS07695 1594377..1594913 - 537 WP_000185703.1 dUTPase -
FORC1_RS07700 1594906..1595088 - 183 WP_000028425.1 hypothetical protein Antitoxin
FORC1_RS07705 1595078..1595329 - 252 WP_001065110.1 DUF1024 family protein Toxin
FORC1_RS07710 1595344..1595586 - 243 WP_000132193.1 hypothetical protein -
FORC1_RS07715 1595601..1595801 - 201 WP_000235324.1 hypothetical protein -
FORC1_RS07720 1595804..1596061 - 258 WP_000022730.1 DUF3310 domain-containing protein -
FORC1_RS07725 1596061..1596462 - 402 WP_000113974.1 PVL family protein -
FORC1_RS07730 1596462..1596647 - 186 WP_001164629.1 DUF3113 family protein -
FORC1_RS07735 1596660..1598612 - 1953 WP_001802096.1 DNA polymerase -
FORC1_RS07740 1598680..1599237 - 558 WP_000645048.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1563460..1620372 56912


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.32 Da        Isoelectric Point: 3.8051

>T49263 WP_001065110.1 NZ_CP009554:c1595329-1595078 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T49263 NZ_CP009554:c1595329-1595078 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCCGTTATCAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTATATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAAGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6781.65 Da        Isoelectric Point: 4.4421

>AT49263 WP_000028425.1 NZ_CP009554:c1595088-1594906 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT49263 NZ_CP009554:c1595088-1594906 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTACAAGTTATCTGACGGCTCTATTATCAGTCTCATAGACTTTGTTATTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5KJM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1X568

References