Detailed information of TA system TA049259

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 1402372..1403122
• Replicon: chromosome
• Accession: NZ_CP009551
• Organism: Burkholderia pseudomallei PB08298010

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BG24_RS19270
• Protein ID: WP_028359363.1
• Coordinates: 1402372..1402797 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BG24_RS36685
• Protein ID: WP_028359362.1
• Coordinates: 1402790..1403122 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BG24_RS19250	1398128..1399492	+	1365	WP_028359366.1	hypothetical protein	-
BG24_RS19255	1399569..1400150	+	582	WP_038761951.1	hypothetical protein	-
BG24_RS19260	1400598..1401377	+	780	WP_028359365.1	hypothetical protein	-
BG24_RS19265	1401744..1402331	+	588	WP_028359364.1	site-specific integrase	-
BG24_RS19270	1402372..1402797	+	426	WP_028359363.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BG24_RS36685	1402790..1403122	+	333	WP_028359362.1	helix-turn-helix domain-containing protein	Antitoxin
BG24_RS39910	1403424..1404404	+	981	WP_143283571.1	hypothetical protein	-
BG24_RS39915	1404407..1404841	+	435	WP_143283572.1	hypothetical protein	-
BG24_RS36690	1405031..1405297	+	267	WP_076883291.1	hypothetical protein	-
BG24_RS19285	1405466..1405912	+	447	WP_028359360.1	hypothetical protein	-
BG24_RS19290	1405909..1406214	+	306	WP_028359359.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BG24_RS19295	1406765..1407337	+	573	WP_028359358.1	SocA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1393224..1408891	15667

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (92-135)

Antitoxin

• Cro/C1-type helix-turn-helix domain (51-105)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 16282.93 Da
• Isoelectric Point: 10.4451

>T49259 WP_028359363.1 NZ_CP009551:1402372-1402797 [Burkholderia pseudomallei PB08298010]
MKQNWTVVYYNERVKRDVFALPAGNLADYLRLLDLMQEFGADLRMPHSRAMGGGLFELRPKETLIKGQIRATEYGLTRVC
GACERLNQRFPKGKEGIGRVFYCTHVGRHVVVLHSFVKKTQETPRNVLQVARVRLNEVRHD

Nucleotide

• Length: 426 bp

>T49259 NZ_CP009551:1402372-1402797 [Burkholderia pseudomallei PB08298010]
ATGAAACAAAATTGGACAGTCGTCTATTACAACGAGCGCGTCAAGCGCGACGTCTTCGCGCTTCCGGCCGGGAATCTGGC
GGACTATCTGCGGCTCCTGGACCTGATGCAGGAGTTCGGCGCGGATTTGCGTATGCCGCACTCGCGAGCAATGGGGGGCG
GATTGTTTGAGTTGCGACCTAAGGAAACGCTGATTAAAGGTCAGATTCGCGCTACTGAGTACGGCCTGACAAGGGTTTGC
GGGGCATGCGAGCGATTAAATCAGCGCTTCCCTAAGGGGAAGGAAGGCATTGGGCGCGTGTTTTATTGCACCCACGTTGG
GCGACACGTCGTTGTGTTGCACTCTTTCGTGAAGAAGACGCAGGAGACGCCGCGGAACGTGCTGCAGGTCGCACGAGTAC
GTTTGAATGAGGTACGTCATGACTAA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 11838.46 Da
• Isoelectric Point: 9.9225

>AT49259 WP_028359362.1 NZ_CP009551:1402790-1403122 [Burkholderia pseudomallei PB08298010]
MTKVTAKRNPAEGFNPVPHTVDDTERLLAKRSVKAAYDELEDEYSALGAILAARQEAGLTQAQVAKRMGTTASAVSRLEA
SLSSEKHSPSFATLRRYAAACGKRLVITFA

Nucleotide

• Length: 333 bp

>AT49259 NZ_CP009551:1402790-1403122 [Burkholderia pseudomallei PB08298010]
ATGACTAAGGTTACAGCGAAGCGCAATCCAGCAGAGGGATTCAATCCGGTTCCGCACACGGTGGATGATACGGAGCGTCT
GTTGGCAAAGCGCAGTGTCAAAGCCGCCTATGACGAGCTGGAAGATGAATACAGTGCGCTAGGCGCTATCTTGGCGGCCC
GGCAAGAGGCTGGCTTAACGCAGGCGCAGGTAGCTAAGCGCATGGGTACGACGGCATCGGCCGTTTCGCGGTTGGAGGCA
TCGCTGTCAAGCGAAAAGCACTCACCTTCGTTTGCGACTCTGCGCAGATATGCGGCCGCGTGTGGAAAAAGACTGGTCAT
TACGTTCGCTTAA