Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1136664..1137358 Replicon chromosome
Accession NZ_CP009492
Organism Yersinia pestis strain PBM19

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag CH59_RS06080 Protein ID WP_002214787.1
Coordinates 1136664..1136960 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag CH59_RS06085 Protein ID WP_002209924.1
Coordinates 1136960..1137358 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH59_RS06040 1131777..1132478 + 702 Protein_940 integrase arm-type DNA-binding domain-containing protein -
CH59_RS06045 1132561..1133583 + 1023 WP_000255944.1 IS21-like element IS100 family transposase -
CH59_RS06050 1133583..1134362 + 780 WP_001297096.1 IS21-like element IS100kyp family helper ATPase IstB -
CH59_RS06055 1134423..1134950 + 528 Protein_943 site-specific integrase -
CH59_RS06060 1135032..1135217 - 186 WP_002209928.1 hypothetical protein -
CH59_RS06070 1135815..1136075 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
CH59_RS06075 1136138..1136500 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
CH59_RS06080 1136664..1136960 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
CH59_RS06085 1136960..1137358 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
CH59_RS06090 1137758..1140049 - 2292 WP_002209923.1 toprim domain-containing protein -
CH59_RS06095 1140349..1140675 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
CH59_RS26120 1140668..1140820 + 153 WP_002209921.1 hypothetical protein -
CH59_RS06105 1140834..1141034 - 201 WP_002209920.1 AlpA family transcriptional regulator -
CH59_RS06110 1141216..1141548 - 333 WP_002214791.1 hypothetical protein -
CH59_RS06115 1141554..1141790 - 237 WP_002214792.1 hypothetical protein -
CH59_RS06120 1141803..1142168 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T49165 WP_002214787.1 NZ_CP009492:1136664-1136960 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T49165 NZ_CP009492:1136664-1136960 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT49165 WP_002209924.1 NZ_CP009492:1136960-1137358 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT49165 NZ_CP009492:1136960-1137358 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References