Detailed information of TA system TA049157

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2184462..2185162
• Replicon: chromosome
• Accession: NZ_CP009486
• Organism: Burkholderia ubonensis MSMB22

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A104WH78
• Locus tag: BW23_RS09480
• Protein ID: WP_045564958.1
• Coordinates: 2184866..2185162 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: BW23_RS09475
• Protein ID: WP_045564957.1
• Coordinates: 2184462..2184863 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BW23_RS09455	2180137..2181486	-	1350	WP_045564953.1	LLM class flavin-dependent oxidoreductase	-
BW23_RS09460	2181483..2182550	-	1068	WP_045564954.1	LLM class flavin-dependent oxidoreductase	-
BW23_RS09465	2182596..2183537	-	942	WP_045564955.1	ABC transporter substrate-binding protein	-
BW23_RS09470	2183593..2184147	-	555	WP_045564956.1	GNAT family N-acetyltransferase	-
BW23_RS09475	2184462..2184863	-	402	WP_045564957.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BW23_RS09480	2184866..2185162	-	297	WP_045564958.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BW23_RS09485	2185271..2186305	-	1035	WP_045565468.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
BW23_RS09490	2186635..2186907	-	273	WP_042587892.1	hypothetical protein	-
BW23_RS09495	2187122..2187283	+	162	Protein_1957	cytochrome c	-
BW23_RS09500	2187327..2187824	-	498	WP_045564960.1	peptidoglycan-associated lipoprotein Pal	-
BW23_RS09505	2188467..2188688	-	222	Protein_1959	RNA polymerase subunit sigma	-
BW23_RS09510	2188876..2189484	+	609	WP_045564962.1	hypothetical protein	-
BW23_RS09515	2189529..2189948	-	420	WP_052495803.1	carboxypeptidase-like regulatory domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11085.92 Da
• Isoelectric Point: 9.5736

>T49157 WP_045564958.1 NZ_CP009486:c2185162-2184866 [Burkholderia ubonensis MSMB22]
MEKNTPHCKLSRVKALVETGKVRLTASAVIGARQLGFTEMDAIGVVMSLTTVDFHKSMTTYADHTIWQDVYRRRTVRGDV
YLKLTVIDDVLIVAFKEQ

Nucleotide

• Length: 297 bp

>T49157 NZ_CP009486:c2185162-2184866 [Burkholderia ubonensis MSMB22]
ATGGAAAAGAATACGCCTCACTGCAAGCTGTCCCGAGTCAAAGCGCTCGTCGAGACCGGCAAGGTGCGTTTGACCGCGAG
TGCGGTAATCGGCGCTCGGCAACTTGGCTTCACCGAAATGGACGCGATCGGTGTCGTGATGTCGCTGACAACCGTCGATT
TCCACAAGAGCATGACGACCTATGCCGACCACACGATATGGCAGGACGTGTATCGGCGCCGCACCGTGCGTGGCGACGTG
TATCTGAAACTGACAGTGATCGACGACGTGCTGATCGTCGCGTTCAAGGAGCAATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14505.86 Da
• Isoelectric Point: 8.4900

>AT49157 WP_045564957.1 NZ_CP009486:c2184863-2184462 [Burkholderia ubonensis MSMB22]
MKCPACGAAKLIRDTRDIPYTYKGRSTVVPGITGDFCPACGESVLDVDEATRLGEAVTEFNKQVNATIVDPKFIAKVRKK
LMLDQREAAELFGGGINAFSRYETGKTNPPLALVKLLKILDRHPELLAEVRAA

Nucleotide

• Length: 402 bp

>AT49157 NZ_CP009486:c2184863-2184462 [Burkholderia ubonensis MSMB22]
ATGAAGTGTCCTGCGTGCGGTGCCGCAAAACTGATCCGCGACACACGAGACATTCCCTATACCTACAAGGGTCGATCGAC
GGTCGTCCCGGGAATAACGGGCGATTTTTGTCCGGCCTGCGGAGAGTCGGTGCTGGACGTCGACGAGGCGACCCGTCTCG
GCGAAGCGGTCACGGAGTTCAACAAGCAGGTGAACGCGACCATCGTCGACCCGAAGTTCATCGCGAAGGTGCGCAAGAAG
CTGATGCTGGATCAGCGTGAGGCGGCGGAACTCTTCGGCGGCGGCATCAATGCGTTCTCCCGCTACGAGACCGGCAAGAC
GAACCCGCCGCTCGCGCTGGTGAAGTTGTTGAAGATCCTGGACCGTCATCCGGAGCTGCTTGCCGAAGTACGCGCGGCGT
AG

Structures

Toxin

• AlphaFold DB: A0A104WH78