Detailed information of TA system TA049154

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 2579546..2580203
• Replicon: chromosome
• Accession: NZ_CP009485
• Organism: Burkholderia pseudomallei MSHR491

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BG17_RS24810
• Protein ID: WP_038799538.1
• Coordinates: 2579546..2579878 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BG17_RS38055
• Protein ID: WP_076898813.1
• Coordinates: 2579871..2580203 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BG17_RS24785	2574740..2575666	+	927	WP_011852346.1	hypothetical protein	-
BG17_RS24790	2575663..2577009	+	1347	WP_038799541.1	type II secretory pathway protein	-
BG17_RS24795	2577023..2577256	-	234	WP_038726517.1	hypothetical protein	-
BG17_RS24800	2577771..2578550	+	780	WP_038799540.1	hypothetical protein	-
BG17_RS24805	2578917..2579504	+	588	WP_038799792.1	site-specific integrase	-
BG17_RS24810	2579546..2579878	+	333	WP_038799538.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BG17_RS38055	2579871..2580203	+	333	WP_076898813.1	helix-turn-helix domain-containing protein	Antitoxin
BG17_RS40410	2580475..2580660	+	186	WP_128972353.1	hypothetical protein	-
BG17_RS31895	2580719..2582182	+	1464	WP_063840451.1	dNTP triphosphohydrolase	-
BG17_RS38060	2582481..2582705	-	225	WP_004195757.1	hypothetical protein	-
BG17_RS24830	2582915..2583232	+	318	WP_004266306.1	hypothetical protein	-
BG17_RS24835	2583746..2584390	+	645	WP_004195754.1	lytic polysaccharide monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2566538..2580203	13665

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (19-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (52-105)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12744.83 Da
• Isoelectric Point: 10.6909

>T49154 WP_038799538.1 NZ_CP009485:2579546-2579878 [Burkholderia pseudomallei MSHR491]
MRKNWTIAYYNERVKRDVFAFPAGVLADYLRLLDLMQEFGADLRMPHSRAMGGGLFELRPKGREGIGRVFYCTHVGRQVV
VLHSFVKKTQETPQHELRIAQARLKEVRNG

Nucleotide

• Length: 333 bp

>T49154 NZ_CP009485:2579546-2579878 [Burkholderia pseudomallei MSHR491]
ATGAGAAAAAATTGGACGATTGCCTACTACAACGAGCGCGTCAAGCGCGACGTCTTCGCGTTCCCGGCTGGAGTTCTTGC
GGACTATCTCCGGCTGTTGGATCTGATGCAAGAATTCGGGGCCGATCTACGGATGCCACACTCCCGAGCAATGGGTGGCG
GGCTGTTTGAATTGCGTCCCAAGGGTAGGGAAGGTATCGGGCGGGTGTTCTACTGCACGCATGTGGGGCGGCAAGTCGTT
GTGCTGCACTCTTTCGTCAAGAAGACTCAGGAAACGCCGCAACATGAGTTGCGGATCGCTCAAGCACGTTTGAAGGAGGT
GCGTAATGGCTAA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 11776.40 Da
• Isoelectric Point: 10.5205

>AT49154 WP_076898813.1 NZ_CP009485:2579871-2580203 [Burkholderia pseudomallei MSHR491]
MAKVAAKRARAEGFNPVLHTAQDTARLLAGHNVRSAYDALEDEYTALRAILSARRDAGLTQAQIAERMGTTASAVSRLEA
SLSSEKHSPSFATLRKYAAACGKRLVISFA

Nucleotide

• Length: 333 bp

>AT49154 NZ_CP009485:2579871-2580203 [Burkholderia pseudomallei MSHR491]
ATGGCTAAGGTAGCAGCGAAGCGTGCTCGCGCAGAGGGATTCAATCCAGTTCTGCATACGGCGCAGGATACGGCGCGTCT
GCTCGCCGGTCACAATGTCAGGTCGGCGTATGACGCGCTGGAGGATGAGTACACCGCGTTGCGCGCTATTTTGTCAGCGC
GGCGCGATGCTGGCCTGACACAGGCTCAGATTGCGGAGCGCATGGGCACGACTGCATCGGCGGTTTCGCGGCTCGAGGCC
TCGTTGTCTAGCGAGAAACATTCGCCGTCGTTTGCAACGCTCAGGAAATATGCTGCTGCTTGCGGTAAGCGACTTGTAAT
TTCGTTTGCGTAG