Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4012131..4012792 Replicon chromosome
Accession NZ_CP009459
Organism Cedecea neteri strain ND14a

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LH86_RS18775 Protein ID WP_039304538.1
Coordinates 4012418..4012792 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LH86_RS18770 Protein ID WP_039304535.1
Coordinates 4012131..4012433 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH86_RS18750 4007833..4009359 + 1527 WP_052045618.1 cytosine permease -
LH86_RS18755 4009377..4010276 - 900 WP_039304529.1 LysR family transcriptional regulator -
LH86_RS18760 4010387..4011763 + 1377 WP_039304532.1 MFS transporter -
LH86_RS18765 4011767..4012097 + 331 Protein_3691 DUF4440 domain-containing protein -
LH86_RS18770 4012131..4012433 - 303 WP_039304535.1 XRE family transcriptional regulator Antitoxin
LH86_RS18775 4012418..4012792 - 375 WP_039304538.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LH86_RS18780 4013006..4015108 - 2103 WP_039304541.1 elongation factor G -
LH86_RS18785 4015299..4015607 + 309 WP_039304544.1 helix-turn-helix domain-containing protein -
LH86_RS18790 4015646..4015981 - 336 WP_008455006.1 DUF496 family protein -
LH86_RS18795 4016155..4017213 - 1059 WP_039304547.1 FUSC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(17-89)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14238.57 Da        Isoelectric Point: 7.6722

>T49095 WP_039304538.1 NZ_CP009459:c4012792-4012418 [Cedecea neteri]
MWSIKMTDTFDAWVTASDDMTKACVMAGVVLLKERGPLLGRPHADTVKGSQYANMKELRIQCRGEPLRVFFAFDIKRCAL
LLCAGNKVGNEKRFYDVMVPLADNEFRAHLQQLTEKEQIEWVER

Download         Length: 375 bp

>T49095 NZ_CP009459:c4012792-4012418 [Cedecea neteri]
ATGTGGTCGATAAAAATGACGGATACGTTTGATGCCTGGGTTACAGCGTCAGATGACATGACCAAAGCTTGCGTTATGGC
AGGGGTCGTACTGCTTAAAGAGAGAGGGCCTTTACTTGGCAGGCCTCATGCCGACACGGTGAAGGGATCGCAATACGCCA
ATATGAAAGAGTTGCGGATCCAGTGCCGGGGCGAGCCACTCAGGGTCTTTTTCGCTTTTGATATAAAGCGTTGTGCCCTC
CTGCTCTGTGCGGGAAATAAAGTGGGGAACGAGAAACGCTTTTATGACGTCATGGTGCCATTAGCAGATAACGAGTTTCG
GGCGCACTTACAGCAGTTAACGGAAAAGGAGCAAATAGAATGGGTCGAACGTTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11161.04 Da        Isoelectric Point: 7.2050

>AT49095 WP_039304535.1 NZ_CP009459:c4012433-4012131 [Cedecea neteri]
MGRTLEQWMAEEKPEVVAAAQAMADEMLLNIHLAELRDKVKKTQTEMAQKLGVKQPTVAEMEKKGRDIKLSSLKRYVEAA
GGKVKLDIELPDGTHFNIAL

Download         Length: 303 bp

>AT49095 NZ_CP009459:c4012433-4012131 [Cedecea neteri]
ATGGGTCGAACGTTAGAACAATGGATGGCCGAAGAAAAACCCGAAGTGGTGGCCGCCGCACAGGCCATGGCCGACGAAAT
GCTGCTGAATATCCATCTGGCTGAACTTCGTGACAAAGTCAAAAAAACACAGACTGAGATGGCGCAGAAGCTCGGTGTGA
AGCAGCCCACCGTCGCCGAAATGGAAAAAAAAGGCCGCGACATCAAGCTTTCTTCCCTCAAGCGTTACGTTGAGGCGGCG
GGCGGGAAGGTAAAGCTGGATATCGAGCTGCCGGACGGCACGCACTTCAATATTGCCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References