Detailed information of TA system TA049079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4384145..4384790
• Replicon: chromosome
• Accession: NZ_CP009458
• Organism: Cedecea neteri strain M006

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LH23_RS20395
• Protein ID: WP_081946141.1
• Coordinates: 4384425..4384790 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A1X7JFQ8
• Locus tag: LH23_RS20390
• Protein ID: WP_039297031.1
• Coordinates: 4384145..4384441 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LH23_RS20380	4381740..4382585	-	846	WP_039295223.1	DNA-3-methyladenine glycosylase 2	-
LH23_RS20385	4382747..4384099	+	1353	WP_039295226.1	molecular chaperone	-
LH23_RS20390	4384145..4384441	-	297	WP_039297031.1	XRE family transcriptional regulator	Antitoxin
LH23_RS20395	4384425..4384790	-	366	WP_081946141.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LH23_RS20400	4385063..4386316	+	1254	WP_039295229.1	MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit	-
LH23_RS20405	4386316..4389438	+	3123	WP_039295232.1	MdtB/MuxB family multidrug efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-80)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14451.46 Da
• Isoelectric Point: 9.3589

>T49079 WP_081946141.1 NZ_CP009458:c4384790-4384425 [Cedecea neteri]
MIWRVIFTDYFYFWYQAQPVELRKRLVAAFGNIEFWGPALSRPQADTVKGSRYPNMKELRLLWRGKPYRIFFAFDPHRRA
VVLCGGDKSNDKRFYQAQINVADTQFAHHLTEMEDENENVN

Nucleotide

• Length: 366 bp

>T49079 NZ_CP009458:c4384790-4384425 [Cedecea neteri]
ATGATATGGCGCGTGATATTTACCGACTATTTCTACTTTTGGTATCAGGCCCAGCCCGTAGAGCTCCGCAAACGACTTGT
GGCGGCCTTCGGCAATATTGAGTTCTGGGGGCCTGCTTTAAGCCGCCCACAGGCGGACACGGTAAAGGGATCTCGTTATC
CCAATATGAAGGAATTACGTTTGCTATGGCGCGGCAAGCCATATCGGATCTTTTTTGCTTTTGACCCGCATCGCAGAGCC
GTTGTGCTGTGTGGTGGAGACAAATCAAACGATAAGCGTTTTTATCAGGCGCAGATAAACGTGGCCGATACGCAGTTTGC
ACATCACCTGACAGAAATGGAGGATGAAAATGAAAACGTTAACTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11074.78 Da
• Isoelectric Point: 4.8840

>AT49079 WP_039297031.1 NZ_CP009458:c4384441-4384145 [Cedecea neteri]
MKTLTEVMAEFSPEEQAEIRAMTDVLILETGLQLVREEQGFSQKQVAQKMGISQPAIAAIEQRGNDLKVLTLKRYVEALG
GKLSLHLEFPESDRRFQI

Nucleotide

• Length: 297 bp

>AT49079 NZ_CP009458:c4384441-4384145 [Cedecea neteri]
ATGAAAACGTTAACTGAAGTAATGGCGGAGTTCTCGCCGGAAGAGCAGGCCGAAATCCGCGCAATGACAGACGTCTTAAT
TCTGGAAACCGGGTTGCAGCTGGTGCGCGAGGAACAGGGGTTTTCTCAAAAACAAGTGGCGCAAAAAATGGGTATTTCGC
AACCGGCAATCGCCGCGATTGAACAACGCGGTAACGATCTCAAAGTGCTCACGCTCAAGCGCTACGTTGAGGCGCTGGGC
GGTAAACTTTCGCTGCATCTGGAGTTTCCAGAAAGCGACCGGCGTTTTCAGATATAA

Structures

Antitoxin

• AlphaFold DB: A0A1X7JFQ8