Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4308406..4309067 Replicon chromosome
Accession NZ_CP009458
Organism Cedecea neteri strain M006

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LH23_RS20060 Protein ID WP_039295053.1
Coordinates 4308693..4309067 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LH23_RS20055 Protein ID WP_039295050.1
Coordinates 4308406..4308708 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH23_RS20030 4304478..4305377 - 900 WP_039295038.1 LysR family transcriptional regulator -
LH23_RS20035 4305488..4306864 + 1377 WP_039295041.1 MFS transporter -
LH23_RS20040 4306868..4307242 + 375 WP_039295044.1 hypothetical protein -
LH23_RS20045 4307291..4307749 - 459 WP_039295047.1 tautomerase family protein -
LH23_RS20050 4307766..4308239 - 474 WP_052050387.1 MarR family winged helix-turn-helix transcriptional regulator -
LH23_RS20055 4308406..4308708 - 303 WP_039295050.1 XRE family transcriptional regulator Antitoxin
LH23_RS20060 4308693..4309067 - 375 WP_039295053.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LH23_RS20065 4309283..4311385 - 2103 WP_039295056.1 elongation factor G -
LH23_RS20070 4311576..4311884 + 309 WP_039295059.1 helix-turn-helix domain-containing protein -
LH23_RS20075 4311922..4312257 - 336 WP_039295064.1 DUF496 family protein -
LH23_RS20080 4312431..4313489 - 1059 WP_039295067.1 FUSC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4296233..4309067 12834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14238.57 Da        Isoelectric Point: 7.6722

>T49078 WP_039295053.1 NZ_CP009458:c4309067-4308693 [Cedecea neteri]
MWSIKMTDTFDAWVTASDDMTKACVMAGVVLLKERGPILGRPHADTVKGSQYANMKELRIQCRGEPLRVFFAFDIKRCAI
LLCAGNKVGNEKRFYDVMVPLADNEFRAHLQQLTEKEQIEWVER

Download         Length: 375 bp

>T49078 NZ_CP009458:c4309067-4308693 [Cedecea neteri]
ATGTGGTCGATAAAAATGACGGATACGTTTGATGCCTGGGTTACGGCGTCAGATGACATGACCAAAGCCTGCGTTATGGC
AGGGGTTGTACTGCTTAAAGAGAGAGGGCCTATACTTGGCAGGCCTCATGCCGACACGGTGAAGGGATCGCAATACGCCA
ATATGAAAGAGTTGCGGATCCAGTGCCGGGGCGAGCCACTCAGGGTCTTTTTCGCTTTTGATATAAAGCGTTGTGCCATC
CTGCTCTGTGCGGGAAATAAAGTGGGGAACGAGAAACGCTTTTATGACGTCATGGTGCCATTAGCAGATAACGAGTTTCG
GGCGCACTTACAGCAGTTAACGGAAAAGGAGCAAATAGAATGGGTCGAACGTTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11202.05 Da        Isoelectric Point: 7.2052

>AT49078 WP_039295050.1 NZ_CP009458:c4308708-4308406 [Cedecea neteri]
MGRTLEQWMAEEKPEVVAAAQAMADEMLLNIHLAELRDKVRKTQNEMAQKLGVKQPTVAEMEKKGRDIKLSSLKRYVEAA
GGKVKLDIELPDGTHFNIAL

Download         Length: 303 bp

>AT49078 NZ_CP009458:c4308708-4308406 [Cedecea neteri]
ATGGGTCGAACGTTAGAACAATGGATGGCCGAAGAAAAACCTGAAGTGGTGGCCGCCGCGCAGGCTATGGCCGACGAAAT
GCTGCTGAATATCCATCTGGCTGAACTTCGCGACAAAGTCAGAAAAACGCAGAACGAGATGGCGCAGAAGCTGGGCGTGA
AGCAGCCCACCGTCGCCGAAATGGAAAAAAAAGGGCGTGATATCAAGCTCTCTTCCCTCAAGCGTTACGTTGAGGCGGCG
GGCGGGAAGGTAAAGCTGGATATCGAGCTGCCGGACGGTACGCACTTCAATATTGCCCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References