Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3837568..3838292 Replicon chromosome
Accession NZ_CP009454
Organism Pantoea rwandensis strain ND04

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LH22_RS17645 Protein ID WP_038650259.1
Coordinates 3837568..3837879 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LH22_RS17650 Protein ID WP_038648804.1
Coordinates 3837876..3838292 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH22_RS17620 3833563..3834105 - 543 WP_038648791.1 acireductone dioxygenase -
LH22_RS17625 3834107..3834790 - 684 WP_038648794.1 acireductone synthase -
LH22_RS17630 3834787..3835401 - 615 WP_038648797.1 methylthioribulose 1-phosphate dehydratase -
LH22_RS17635 3835533..3836693 + 1161 WP_038648799.1 pyridoxal phosphate-dependent aminotransferase -
LH22_RS17640 3836681..3837451 + 771 WP_038648801.1 amidohydrolase -
LH22_RS17645 3837568..3837879 + 312 WP_038650259.1 type II toxin-antitoxin system HigB family toxin Toxin
LH22_RS17650 3837876..3838292 + 417 WP_038648804.1 transcriptional regulator Antitoxin
LH22_RS17655 3838336..3840534 - 2199 WP_038648806.1 catalase/peroxidase HPI -
LH22_RS17660 3840928..3841263 - 336 WP_038648808.1 hydroxyisourate hydrolase -
LH22_RS17665 3841260..3841754 - 495 WP_038648810.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LH22_RS17670 3841766..3843025 - 1260 WP_038648815.1 allantoate amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12229.16 Da        Isoelectric Point: 9.7937

>T49051 WP_038650259.1 NZ_CP009454:3837568-3837879 [Pantoea rwandensis]
MHVISRKMFAEAALRFPNDAAALDATYRTLHGRDFADPEALKHFFPSLDRMKYRVKWWVINIGGNNLRLMFFADFIAGCI
FIKHISTHAEYDKWVKFYRENKE

Download         Length: 312 bp

>T49051 NZ_CP009454:3837568-3837879 [Pantoea rwandensis]
ATGCACGTTATTTCAAGGAAGATGTTTGCTGAAGCGGCATTACGCTTTCCCAATGATGCAGCAGCACTGGATGCCACTTA
TCGGACTCTACATGGCAGAGATTTTGCCGACCCTGAAGCACTTAAACACTTTTTTCCAAGCCTGGATCGAATGAAGTATC
GGGTGAAATGGTGGGTGATCAATATTGGTGGCAACAATCTTAGGTTGATGTTTTTTGCCGACTTCATCGCTGGATGTATT
TTCATTAAGCACATCAGTACTCATGCTGAATACGATAAATGGGTTAAGTTCTATCGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15542.78 Da        Isoelectric Point: 6.3365

>AT49051 WP_038648804.1 NZ_CP009454:3837876-3838292 [Pantoea rwandensis]
MIAEAIQASDNLIKAVPLLGGSQSKADYEQALELVEYLVEHQPSHPLIDMLADKVAKYEEHAPEFAAFNARVNTLPGGIA
LLRVLMDQHDLNQSSFIQEIGQRSYVSRILRGERKLTDKHKAALAKRFKLPFEAFRED

Download         Length: 417 bp

>AT49051 NZ_CP009454:3837876-3838292 [Pantoea rwandensis]
ATGATCGCCGAAGCTATTCAGGCCTCAGATAACCTCATCAAAGCCGTCCCCCTGCTTGGCGGTAGTCAATCGAAAGCAGA
TTATGAGCAAGCGTTAGAGCTGGTTGAGTATTTGGTTGAGCATCAGCCCTCTCATCCATTGATTGATATGCTGGCTGATA
AAGTCGCGAAATATGAAGAGCATGCGCCGGAGTTTGCAGCCTTCAATGCACGCGTTAACACCCTGCCGGGCGGAATCGCG
CTGCTGCGTGTATTGATGGATCAACACGATTTAAACCAATCATCATTCATTCAGGAAATTGGTCAGCGTTCTTATGTTAG
CCGTATTTTGAGAGGTGAACGTAAGCTAACGGATAAGCATAAAGCGGCGCTGGCAAAACGTTTTAAACTACCCTTCGAAG
CCTTTCGCGAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References