Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2140235..2140895 Replicon chromosome
Accession NZ_CP009454
Organism Pantoea rwandensis strain ND04

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LH22_RS09745 Protein ID WP_038646106.1
Coordinates 2140235..2140588 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LH22_RS09750 Protein ID WP_038646107.1
Coordinates 2140593..2140895 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH22_RS09725 2135499..2136626 + 1128 WP_038646100.1 ATP-binding cassette domain-containing protein -
LH22_RS09730 2136607..2137263 + 657 WP_038646102.1 ABC transporter permease -
LH22_RS09735 2137549..2138748 + 1200 WP_038646103.1 M20 family metallopeptidase -
LH22_RS09740 2138760..2140064 + 1305 WP_038646105.1 NtaA/DmoA family FMN-dependent monooxygenase -
LH22_RS09745 2140235..2140588 + 354 WP_038646106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LH22_RS09750 2140593..2140895 + 303 WP_038646107.1 XRE family transcriptional regulator Antitoxin
LH22_RS20810 2141231..2141413 - 183 WP_038646109.1 hypothetical protein -
LH22_RS09765 2143119..2143706 + 588 WP_038646118.1 hypothetical protein -
LH22_RS09770 2143718..2144224 + 507 WP_038646120.1 type VI secretion system lipoprotein TssJ -
LH22_RS09775 2144234..2145574 + 1341 WP_038646123.1 type VI secretion system baseplate subunit TssK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-88)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13344.34 Da        Isoelectric Point: 7.7776

>T49048 WP_038646106.1 NZ_CP009454:2140235-2140588 [Pantoea rwandensis]
MWQIVTTDTFDDWLVAQDDTARACVLSALIVLQQAGPALCRPYADTLKGSRFSNMKELRIQSIGVPIRAFYAFDPWRSGV
VLCTGHKSGNEKRFYAGLIPLADKEFMHHLQREERKE

Download         Length: 354 bp

>T49048 NZ_CP009454:2140235-2140588 [Pantoea rwandensis]
ATGTGGCAGATAGTAACAACGGACACTTTTGATGATTGGCTGGTGGCGCAAGATGACACTGCCCGAGCATGCGTCTTGTC
TGCATTAATTGTATTGCAGCAAGCAGGCCCAGCGTTATGCAGGCCTTACGCTGACACCCTAAAAGGCTCTCGTTTTAGCA
ATATGAAAGAGCTTCGTATTCAAAGCATAGGTGTTCCTATCCGGGCTTTTTACGCATTTGATCCCTGGCGCAGCGGTGTA
GTGCTTTGCACAGGTCATAAGAGTGGCAATGAAAAGCGTTTTTATGCCGGGCTGATCCCGCTCGCAGATAAAGAATTCAT
GCATCATCTTCAACGCGAAGAGAGAAAGGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11175.97 Da        Isoelectric Point: 6.4769

>AT49048 WP_038646107.1 NZ_CP009454:2140593-2140895 [Pantoea rwandensis]
MGRTLEQILAAERPEVVAEANAMAEEVLLNIHLAELRERVKKTQVEIAQQLNIKQPTVAGMEKPGRDLKLSTLKRYVEAA
GGKLRLNIELPDGSHYEFVV

Download         Length: 303 bp

>AT49048 NZ_CP009454:2140593-2140895 [Pantoea rwandensis]
ATGGGCAGAACACTTGAACAAATTCTTGCAGCTGAGAGGCCGGAAGTGGTGGCTGAAGCTAACGCCATGGCTGAAGAAGT
CTTACTGAATATCCACCTTGCTGAATTGCGTGAAAGAGTAAAAAAAACTCAAGTGGAGATCGCGCAACAATTAAATATTA
AACAGCCTACGGTTGCAGGAATGGAGAAACCCGGCCGGGATTTAAAACTCTCGACGCTTAAGCGTTATGTTGAAGCTGCA
GGAGGAAAACTCCGCCTTAACATTGAGCTTCCCGATGGCTCGCATTACGAGTTTGTCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References