Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 750735..751418 Replicon chromosome
Accession NZ_CP009454
Organism Pantoea rwandensis strain ND04

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LH22_RS20010 Protein ID WP_071845581.1
Coordinates 750735..751043 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LH22_RS03345 Protein ID WP_038644208.1
Coordinates 751086..751418 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH22_RS03320 746029..746523 + 495 WP_038644203.1 GNAT family N-acetyltransferase -
LH22_RS03325 746796..747710 - 915 WP_038644204.1 sugar ABC transporter substrate-binding protein -
LH22_RS03330 748179..749573 + 1395 WP_038644205.1 MFS transporter -
LH22_RS03335 749554..750513 + 960 WP_038644206.1 2-hydroxyacid dehydrogenase -
LH22_RS20010 750735..751043 + 309 WP_071845581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LH22_RS03345 751086..751418 + 333 WP_038644208.1 HigA family addiction module antidote protein Antitoxin
LH22_RS03350 751682..752845 + 1164 WP_038644209.1 HD-GYP domain-containing protein -
LH22_RS20015 752954..753043 + 90 WP_064511346.1 K(+)-transporting ATPase subunit F -
LH22_RS03355 753043..754722 + 1680 WP_038644210.1 potassium-transporting ATPase subunit KdpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 12170.02 Da        Isoelectric Point: 10.0976

>T49045 WP_071845581.1 NZ_CP009454:750735-751043 [Pantoea rwandensis]
MKGAIRHFRDDWLEQFFIYALPHRCLPKTIESALARKLDIINAAKTHRDLRSPPGNRFEALKPPLLGYYSIRVNEQYRLI
FRWMNGEASDLYLDPHSYKNHR

Download         Length: 309 bp

>T49045 NZ_CP009454:750735-751043 [Pantoea rwandensis]
ATGAAGGGTGCAATTAGACATTTTCGGGATGATTGGCTTGAGCAATTTTTTATTTATGCCTTACCACACAGGTGCCTCCC
CAAAACAATTGAATCCGCGCTCGCGCGTAAGCTCGATATCATCAATGCCGCTAAAACGCATCGTGACCTGCGCTCGCCGC
CCGGAAATCGTTTTGAAGCCCTGAAGCCTCCTTTGCTGGGGTATTACTCCATCCGCGTTAATGAGCAATATCGACTCATA
TTTCGCTGGATGAATGGCGAAGCCAGCGATCTTTATCTCGATCCGCATTCTTATAAAAACCACCGATAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12789.51 Da        Isoelectric Point: 5.7065

>AT49045 WP_038644208.1 NZ_CP009454:751086-751418 [Pantoea rwandensis]
MNQAKRKPTSVGDVLQYEFLEPLHLKVNDLAEMLNVHRNTASAMVNNNRKLTTEMAYRLAAVFDTSVDFWLNLQRYQDQW
EVENDARTQEELSRVIPLSTFMAQRGMQVA

Download         Length: 333 bp

>AT49045 NZ_CP009454:751086-751418 [Pantoea rwandensis]
ATGAATCAGGCAAAACGTAAGCCCACCAGTGTTGGTGATGTGCTGCAGTATGAGTTCCTCGAACCCCTTCATCTCAAAGT
GAATGATTTAGCTGAGATGCTGAATGTGCACAGGAACACCGCCAGTGCGATGGTCAATAACAATCGCAAACTGACTACAG
AAATGGCATACCGTTTAGCGGCCGTTTTTGATACTTCCGTTGATTTCTGGCTCAACCTCCAGCGTTATCAGGACCAATGG
GAAGTTGAAAATGATGCCCGCACGCAGGAAGAGTTAAGCCGTGTCATCCCGCTAAGCACTTTTATGGCACAGCGCGGTAT
GCAGGTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References