Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 497930..498584 Replicon chromosome
Accession NZ_CP009454
Organism Pantoea rwandensis strain ND04

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LH22_RS02190 Protein ID WP_038643949.1
Coordinates 497930..498286 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LH22_RS02195 Protein ID WP_038643950.1
Coordinates 498279..498584 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH22_RS02165 493154..494302 - 1149 WP_038643943.1 galactonate dehydratase -
LH22_RS02170 494299..494916 - 618 WP_038643945.1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase -
LH22_RS02175 494900..495775 - 876 WP_038643946.1 2-dehydro-3-deoxygalactonokinase -
LH22_RS02180 495772..496470 - 699 WP_034829999.1 FadR family transcriptional regulator -
LH22_RS02185 496916..497725 - 810 WP_038643948.1 sugar-phosphatase -
LH22_RS02190 497930..498286 + 357 WP_038643949.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LH22_RS02195 498279..498584 + 306 WP_038643950.1 helix-turn-helix transcriptional regulator Antitoxin
LH22_RS02200 498633..501041 - 2409 WP_038643951.1 DNA topoisomerase (ATP-hydrolyzing) subunit B -
LH22_RS02205 501059..502144 - 1086 WP_034830004.1 DNA replication/repair protein RecF -
LH22_RS02210 502324..503424 - 1101 WP_034830010.1 DNA polymerase III subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13594.49 Da        Isoelectric Point: 6.9672

>T49044 WP_038643949.1 NZ_CP009454:497930-498286 [Pantoea rwandensis]
MWQVQLTEPFEEWLLQQDSGLRKRVAAALLNLQHYGPLLPRPYADTVSGSRFHNMKELRVQYAGHPIRAFYAFDIQRKAI
VLCAGDKTGDKHFYQRMIESADEIFSCHLADLEGKAND

Download         Length: 357 bp

>T49044 NZ_CP009454:497930-498286 [Pantoea rwandensis]
ATGTGGCAGGTCCAATTAACCGAACCGTTTGAGGAGTGGTTGCTCCAGCAAGATAGCGGCTTAAGAAAACGCGTCGCGGC
AGCATTATTAAACCTTCAGCATTATGGCCCATTGCTCCCCCGCCCCTACGCTGACACGGTGAGCGGATCGCGCTTTCACA
ATATGAAAGAGCTCAGGGTGCAATATGCGGGTCACCCTATTCGCGCGTTTTATGCGTTCGATATTCAGCGTAAAGCTATC
GTGTTGTGTGCTGGAGATAAAACGGGTGATAAGCATTTTTATCAGCGCATGATTGAATCTGCCGATGAAATTTTTTCCTG
CCACCTGGCTGATCTGGAGGGTAAAGCAAATGACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11262.98 Da        Isoelectric Point: 4.4189

>AT49044 WP_038643950.1 NZ_CP009454:498279-498584 [Pantoea rwandensis]
MTDLKDFLNDAFSASERADIQQMADELILETGLQLLREELELSQKTVAEAMGVKQPRITQIEQAGADQRLITIKRYIEAM
GGKLSLLIEMPDGSVGRTIRV

Download         Length: 306 bp

>AT49044 NZ_CP009454:498279-498584 [Pantoea rwandensis]
ATGACTGACCTTAAAGACTTTTTGAATGACGCCTTTTCTGCCTCTGAACGTGCTGACATTCAGCAAATGGCTGATGAGCT
GATCCTGGAAACCGGATTGCAGCTATTGCGCGAGGAGTTGGAGCTGTCACAAAAAACAGTGGCTGAAGCGATGGGGGTGA
AGCAACCTCGTATCACACAGATTGAACAAGCGGGAGCCGATCAGCGCCTGATTACTATTAAACGTTATATTGAGGCGATG
GGTGGAAAACTCAGCTTGTTGATTGAAATGCCGGACGGATCCGTAGGCAGGACGATTCGGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References