Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4315412..4316057 Replicon chromosome
Accession NZ_CP009451
Organism Cedecea neteri strain SSMD04

Toxin (Protein)


Gene name higB Uniprot ID A0A089RKC2
Locus tag JT31_RS19930 Protein ID WP_038481209.1
Coordinates 4315412..4315765 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A089Q6K5
Locus tag JT31_RS19935 Protein ID WP_038483358.1
Coordinates 4315761..4316057 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT31_RS19920 4310766..4313888 - 3123 WP_038481203.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -
JT31_RS19925 4313888..4315141 - 1254 WP_038481206.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
JT31_RS19930 4315412..4315765 + 354 WP_038481209.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JT31_RS19935 4315761..4316057 + 297 WP_038483358.1 helix-turn-helix transcriptional regulator Antitoxin
JT31_RS19940 4316109..4317461 - 1353 WP_038481212.1 molecular chaperone -
JT31_RS19945 4317623..4318468 + 846 WP_038481215.1 DNA-3-methyladenine glycosylase 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13887.96 Da        Isoelectric Point: 9.8113

>T49028 WP_038481209.1 NZ_CP009451:4315412-4315765 [Cedecea neteri]
MTWTVIFTDYFYFWYQAQPLDLRKRLAAAFGNLEFWGPELSRPQADTVKGSRYPNMKELRLLWRGKPYRIFFAFDPRRRA
VVLCGGDKSGNKRFYETLIKVADTQLAHHLAELESEY

Download         Length: 354 bp

>T49028 NZ_CP009451:4315412-4315765 [Cedecea neteri]
ATGACATGGACCGTAATTTTTACCGACTATTTCTATTTTTGGTATCAGGCGCAGCCTTTGGATCTCCGCAAACGGCTCGC
GGCAGCCTTCGGAAATCTTGAGTTCTGGGGGCCTGAGTTGAGCCGTCCGCAGGCTGATACAGTAAAAGGCTCCCGCTATC
CCAATATGAAGGAGCTGCGCCTGCTGTGGCGGGGGAAGCCGTATCGAATATTTTTTGCTTTTGATCCAAGGCGCAGGGCC
GTTGTGCTGTGCGGTGGAGATAAATCAGGTAACAAACGGTTTTATGAGACTTTGATAAAAGTGGCTGATACGCAGTTGGC
GCACCACCTGGCAGAACTGGAGAGTGAATATTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11030.83 Da        Isoelectric Point: 7.0164

>AT49028 WP_038483358.1 NZ_CP009451:4315761-4316057 [Cedecea neteri]
IKTLTEVIAGFSPEDQAEIRKMTEVLILETGLQLVREEQGLSQKQVAQKMGISQPAIAAIEQRGNDLKVLTLKRYVEALG
GKLSLHLEFPEKDRRFQI

Download         Length: 297 bp

>AT49028 NZ_CP009451:4315761-4316057 [Cedecea neteri]
ATTAAAACCTTAACTGAAGTGATTGCCGGGTTCTCGCCGGAAGACCAGGCAGAGATCCGAAAAATGACCGAAGTCCTGAT
TCTGGAAACTGGCCTGCAGCTGGTGCGTGAAGAGCAGGGACTTTCTCAAAAGCAAGTGGCGCAAAAAATGGGAATTTCGC
AGCCGGCGATAGCCGCCATCGAACAACGCGGTAACGATCTTAAGGTTCTTACCCTCAAGCGCTACGTTGAGGCCCTGGGC
GGCAAACTTTCGCTGCATCTGGAATTTCCGGAAAAGGACAGGCGTTTTCAGATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A089RKC2

Antitoxin

Source ID Structure
AlphaFold DB A0A089Q6K5

References