Detailed information of TA system TA049001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1080806..1081470
• Replicon: chromosome
• Accession: NZ_CP009450
• Organism: Pluralibacter gergoviae strain FB2

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A1S2B9G4
• Locus tag: LG71_RS05055
• Protein ID: WP_048254840.1
• Coordinates: 1080806..1081066 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: LG71_RS05060
• Protein ID: WP_199533722.1
• Coordinates: 1081198..1081470 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LG71_RS05040	1076812..1078764	+	1953	WP_043081596.1	glycoside hydrolase family 3 protein	-
LG71_RS05045	1078807..1079616	-	810	WP_043081597.1	dienelactone hydrolase family protein	-
LG71_RS05050	1079871..1080632	+	762	WP_043081598.1	uridine phosphorylase	-
LG71_RS05055	1080806..1081066	+	261	WP_048254840.1	type II toxin-antitoxin system MqsR family toxin	Toxin
LG71_RS27725	1081069..1081194	+	126	WP_199533721.1	type II toxin-antitoxin system MqsA family antitoxin	-
LG71_RS05060	1081198..1081470	+	273	WP_199533722.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
LG71_RS05065	1081540..1082943	+	1404	WP_043081600.1	DNA recombination protein RmuC	-
LG71_RS05070	1083019..1083774	+	756	WP_043081601.1	bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE	-
LG71_RS05075	1083787..1084392	+	606	WP_043081602.1	SCP2 domain-containing protein	-
LG71_RS05080	1084389..1086029	+	1641	WP_043081603.1	ubiquinone biosynthesis regulatory protein kinase UbiB	-
LG71_RS05085	1086104..1086364	+	261	WP_043081604.1	Sec-independent protein translocase subunit TatA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-85)

Antitoxin

• Antitoxin MqsA/HigA-2 (2-88)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9824.42 Da
• Isoelectric Point: 10.4380

>T49001 WP_048254840.1 NZ_CP009450:1080806-1081066 [Pluralibacter gergoviae]
MVSQGKLRVTANAFDGAALLGFSFPLAVSIASLINSLKPYDFYKSRTAYHDRTIWHDVYRVGRHQRQIYLKLIVQGDVLI
VSLKER

Nucleotide

• Length: 261 bp

>T49001 NZ_CP009450:1080806-1081066 [Pluralibacter gergoviae]
ATGGTGTCTCAGGGTAAATTGAGGGTAACTGCAAACGCTTTCGACGGTGCCGCCTTACTCGGGTTTAGCTTTCCCTTAGC
CGTCAGTATTGCCAGTCTTATCAACTCCCTGAAACCTTATGACTTTTATAAAAGCAGGACTGCTTATCACGATCGCACAA
TCTGGCATGATGTTTATCGCGTTGGCCGGCATCAGCGACAAATCTATTTGAAGCTGATTGTGCAGGGGGATGTACTCATT
GTGTCCCTGAAGGAGCGATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10389.75 Da
• Isoelectric Point: 9.0681

>AT49001 WP_199533722.1 NZ_CP009450:1081198-1081470 [Pluralibacter gergoviae]
MLDGEEGDRYARHMHDCRKSVNAREVDPAFIAAVRRRLNLDQRQAAEFFGGGVNAFSRYETGKVAPPRPRVLLFKAFDKH
PELFDELRQT

Nucleotide

• Length: 273 bp

>AT49001 NZ_CP009450:1081198-1081470 [Pluralibacter gergoviae]
TTGCTCGACGGCGAGGAGGGAGACAGATATGCCCGCCATATGCACGACTGCCGAAAAAGCGTAAATGCCAGAGAAGTCGA
TCCGGCATTTATTGCGGCAGTGCGCCGACGCTTAAATCTCGATCAGCGTCAGGCGGCGGAGTTCTTCGGTGGGGGCGTAA
ACGCATTTAGCCGCTATGAAACAGGTAAGGTCGCGCCGCCGCGGCCGCGGGTACTACTGTTTAAAGCCTTTGATAAACAT
CCCGAACTTTTTGATGAGCTCAGGCAGACGTGA

Structures

Toxin

• AlphaFold DB: A0A1S2B9G4