Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2985435..2986083 Replicon chromosome
Accession NZ_CP009427
Organism Mycobacterium tuberculosis strain 96121

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag HR37_RS14140 Protein ID WP_003903987.1
Coordinates 2985435..2985758 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag HR37_RS14145 Protein ID WP_003899415.1
Coordinates 2985838..2986083 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR37_RS14110 2980758..2981756 + 999 WP_003908027.1 tyrosine-type recombinase/integrase -
HR37_RS14115 2981770..2982234 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
HR37_RS14120 2982222..2982473 + 252 WP_003908028.1 hypothetical protein -
HR37_RS14125 2982644..2984083 - 1440 WP_003901443.1 phage major capsid protein -
HR37_RS14130 2984091..2984624 - 534 WP_003899412.1 HK97 family phage prohead protease -
HR37_RS21650 2984777..2985268 - 492 WP_003900541.1 phage terminase small subunit P27 family -
HR37_RS14140 2985435..2985758 - 324 WP_003903987.1 type II toxin-antitoxin system toxin Toxin
HR37_RS14145 2985838..2986083 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
HR37_RS14150 2986080..2987507 - 1428 WP_003908030.1 DUF3631 domain-containing protein -
HR37_RS14155 2987509..2987901 - 393 WP_003899417.1 DUF2742 domain-containing protein -
HR37_RS14160 2987898..2988158 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
HR37_RS14165 2988175..2988537 - 363 WP_003900543.1 hypothetical protein -
HR37_RS14170 2988540..2989667 - 1128 WP_003899420.1 site-specific integrase -
HR37_RS14175 2989812..2990039 - 228 WP_003899421.1 hypothetical protein -
HR37_RS21655 2990036..2990425 - 390 WP_003899422.1 hypothetical protein -
HR37_RS14180 2990331..2990603 + 273 WP_003900544.1 hypothetical protein -
HR37_RS14185 2990702..2990935 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2980758..2989667 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12353.82 Da        Isoelectric Point: 7.4705

>T48979 WP_003903987.1 NZ_CP009427:c2985758-2985435 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMMLGWHPYQFPDEPDSKQ

Download         Length: 324 bp

>T48979 NZ_CP009427:c2985758-2985435 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCTGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGATGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT48979 WP_003899415.1 NZ_CP009427:c2986083-2985838 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT48979 NZ_CP009427:c2986083-2985838 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References