48867

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2562093..2562610 Replicon chromosome
Accession NZ_CP009423
Organism Staphylococcus aureus strain USA300_SUR1

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag LG33_RS13650 Protein ID WP_000113262.1
Coordinates 2562093..2562359 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag LG33_RS13655 Protein ID WP_000584502.1
Coordinates 2562359..2562610 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG33_RS13625 2557519..2558055 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
LG33_RS13630 2558288..2559112 - 825 WP_000572040.1 formate/nitrite transporter family protein -
LG33_RS13635 2559329..2559511 - 183 WP_000230294.1 hypothetical protein -
LG33_RS13640 2559595..2560062 - 468 WP_000153344.1 SRPBCC domain-containing protein -
LG33_RS13645 2560248..2561798 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
LG33_RS15815 2561987..2562058 - 72 Protein_2523 hypothetical protein -
LG33_RS13650 2562093..2562359 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
LG33_RS13655 2562359..2562610 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LG33_RS13660 2562775..2562876 - 102 WP_001791744.1 hypothetical protein -
LG33_RS13665 2562883..2563482 - 600 WP_000162813.1 DsbA family protein -
LG33_RS13670 2563501..2563860 - 360 WP_000819847.1 DUF4467 domain-containing protein -
LG33_RS13675 2564115..2565365 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
LG33_RS13680 2565462..2566193 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
LG33_RS13685 2566190..2566909 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T48867 WP_000113262.1 NZ_CP009423:c2562359-2562093 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T48867 NZ_CP009423:c2562359-2562093 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT48867 WP_000584502.1 NZ_CP009423:c2562610-2562359 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT48867 NZ_CP009423:c2562610-2562359 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References