Detailed information of TA system TA048859

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2122547..2122846
• Replicon: chromosome
• Accession: NZ_CP009423
• Organism: Staphylococcus aureus strain USA300_SUR1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: LG33_RS11190
• Protein ID: WP_011447039.1
• Coordinates: 2122670..2122846 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2122547..2122602 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LG33_RS11135	2117878..2118138	+	261	WP_001791826.1	hypothetical protein	-
LG33_RS11140	2118191..2118541	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
LG33_RS11145	2119226..2119675	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
LG33_RS15800	2119770..2120105	-	336	Protein_2059	SH3 domain-containing protein	-
LG33_RS11170	2120755..2121246	-	492	WP_000919350.1	staphylokinase	-
LG33_RS11175	2121437..2122192	-	756	WP_000861038.1	CHAP domain-containing protein	-
LG33_RS11180	2122204..2122458	-	255	WP_000611512.1	phage holin	-
LG33_RS11185	2122510..2122617	+	108	WP_001791821.1	hypothetical protein	-
-	2122539..2122678	+	140	NuclAT_0	-	-
-	2122539..2122678	+	140	NuclAT_0	-	-
-	2122539..2122678	+	140	NuclAT_0	-	-
-	2122539..2122678	+	140	NuclAT_0	-	-
-	2122547..2122602	+	56	-	-	Antitoxin
LG33_RS11190	2122670..2122846	-	177	WP_011447039.1	putative holin-like toxin	Toxin
LG33_RS11195	2122996..2123292	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
LG33_RS11200	2123350..2123637	-	288	WP_001040261.1	hypothetical protein	-
LG33_RS11205	2123684..2123836	-	153	WP_001153681.1	hypothetical protein	-
LG33_RS11210	2123826..2127611	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2118191..2174138	55947

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T48859 WP_011447039.1 NZ_CP009423:c2122846-2122670 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T48859 NZ_CP009423:c2122846-2122670 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT48859 NZ_CP009423:2122547-2122602 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin