Detailed information of TA system TA048854

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1901345..1901759
• Replicon: chromosome
• Accession: NZ_CP009423
• Organism: Staphylococcus aureus strain USA300_SUR1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LG33_RS09715
• Protein ID: WP_076035555.1
• Coordinates: 1901508..1901759 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LG33_RS15905
• Protein ID: WP_000028424.1
• Coordinates: 1901345..1901518 (-)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LG33_RS09675	1897495..1898772	-	1278	WP_000169945.1	PBSX family phage terminase large subunit	-
LG33_RS09680	1898759..1899199	-	441	WP_001003271.1	terminase small subunit	-
LG33_RS09685	1899386..1899805	-	420	WP_000058632.1	transcriptional regulator	-
LG33_RS09690	1899820..1899966	-	147	WP_000990005.1	hypothetical protein	-
LG33_RS09695	1899967..1900140	-	174	WP_031924097.1	transcriptional activator RinB	-
LG33_RS09700	1900137..1900343	-	207	WP_031764620.1	DUF1381 domain-containing protein	-
LG33_RS09705	1900380..1900886	-	507	WP_076035554.1	dUTPase	-
LG33_RS15900	1900901..1901062	-	162	WP_000889682.1	hypothetical protein	-
LG33_RS09710	1901063..1901344	-	282	WP_000454994.1	hypothetical protein	-
LG33_RS15905	1901345..1901518	-	174	WP_000028424.1	hypothetical protein	Antitoxin
LG33_RS09715	1901508..1901759	-	252	WP_076035555.1	DUF1024 family protein	Toxin
LG33_RS09720	1901752..1902141	-	390	WP_033861700.1	hypothetical protein	-
LG33_RS09725	1902138..1902485	-	348	WP_000979209.1	hypothetical protein	-
LG33_RS09730	1902485..1902676	-	192	WP_076035556.1	hypothetical protein	-
LG33_RS09735	1902673..1903053	-	381	WP_076035557.1	hypothetical protein	-
LG33_RS09740	1903067..1903315	-	249	WP_076035558.1	phi PVL orf 51-like protein	-
LG33_RS09745	1903316..1903825	-	510	WP_076035559.1	hypothetical protein	-
LG33_RS09750	1903826..1904011	-	186	WP_072512743.1	DUF3113 family protein	-
LG33_RS09755	1904016..1904420	-	405	WP_076035560.1	DUF1064 domain-containing protein	-
LG33_RS09760	1904431..1904652	-	222	WP_001123685.1	DUF3269 family protein	-
LG33_RS09765	1904655..1904870	-	216	WP_001024406.1	hypothetical protein	-
LG33_RS09770	1904867..1906108	-	1242	WP_001106169.1	AAA family ATPase	-
LG33_RS09775	1906105..1906461	-	357	WP_031764163.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1873314..1924830	51516

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9393.35 Da
• Isoelectric Point: 3.8569

>T48854 WP_076035555.1 NZ_CP009423:c1901759-1901508 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQLSVKEGIELDEAVGIMAGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T48854 NZ_CP009423:c1901759-1901508 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTGATCAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACTTTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT48854 WP_000028424.1 NZ_CP009423:c1901518-1901345 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT48854 NZ_CP009423:c1901518-1901345 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA