Detailed information of TA system TA048850

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1119648..1120245
• Replicon: chromosome
• Accession: NZ_CP009420
• Organism: Neisseria meningitidis strain NM3682

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: LA58_RS05900
• Protein ID: WP_002242826.1
• Coordinates: 1119967..1120245 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LA58_RS05895
• Protein ID: WP_002221020.1
• Coordinates: 1119648..1119959 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA58_RS13875	1115515..1115679	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
LA58_RS05880	1115679..1116290	+	612	WP_002224558.1	baseplate J/gp47 family protein	-
LA58_RS05885	1116287..1116847	+	561	WP_002213590.1	YmfQ family protein	-
LA58_RS05890	1116858..1118831	+	1974	WP_002248050.1	pyocin knob domain-containing protein	-
LA58_RS05895	1119648..1119959	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
LA58_RS05900	1119967..1120245	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LA58_RS05905	1120330..1120935	+	606	WP_002219301.1	hypothetical protein	-
LA58_RS05910	1120914..1121210	+	297	WP_002221017.1	hypothetical protein	-
LA58_RS05915	1121207..1121416	+	210	WP_002222487.1	hypothetical protein	-
LA58_RS05920	1121526..1122669	-	1144	Protein_1124	ABC transporter ATP-binding protein/permease	-
LA58_RS05935	1123111..1123758	-	648	WP_002217218.1	DUF799 domain-containing protein	-
LA58_RS05940	1123755..1124123	-	369	WP_002219297.1	DUF4810 domain-containing protein	-
LA58_RS05945	1124133..1124804	-	672	WP_002217215.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	952684..1126925	174241
	-	flank	IS/Tn	-	-	1114485..1115450	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T48850 WP_002242826.1 NZ_CP009420:c1120245-1119967 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T48850 NZ_CP009420:c1120245-1119967 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT48850 WP_002221020.1 NZ_CP009420:c1119959-1119648 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT48850 NZ_CP009420:c1119959-1119648 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6