Detailed information of TA system TA048849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1319005..1319602
• Replicon: chromosome
• Accession: NZ_CP009419
• Organism: Neisseria meningitidis M7124

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: LA24_RS07010
• Protein ID: WP_002242826.1
• Coordinates: 1319324..1319602 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LA24_RS07005
• Protein ID: WP_002221020.1
• Coordinates: 1319005..1319316 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA24_RS13800	1314923..1315087	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
LA24_RS06990	1315087..1315698	+	612	WP_002224558.1	baseplate J/gp47 family protein	-
LA24_RS06995	1315695..1316255	+	561	WP_002213590.1	YmfQ family protein	-
LA24_RS07000	1316266..1318239	+	1974	WP_002248050.1	pyocin knob domain-containing protein	-
LA24_RS07005	1319005..1319316	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
LA24_RS07010	1319324..1319602	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LA24_RS07015	1319687..1320292	+	606	WP_002219301.1	hypothetical protein	-
LA24_RS07020	1320271..1320567	+	297	WP_002221017.1	hypothetical protein	-
LA24_RS07025	1320564..1320773	+	210	WP_002222487.1	hypothetical protein	-
LA24_RS07030	1320883..1322026	-	1144	Protein_1318	ABC transporter ATP-binding protein/permease	-
LA24_RS07045	1322468..1323115	-	648	WP_002217218.1	DUF799 domain-containing protein	-
LA24_RS07050	1323112..1323480	-	369	WP_002219297.1	DUF4810 domain-containing protein	-
LA24_RS07055	1323490..1324161	-	672	WP_002217215.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1304696..1320567	15871
	-	flank	IS/Tn	-	-	1313893..1314858	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T48849 WP_002242826.1 NZ_CP009419:c1319602-1319324 [Neisseria meningitidis M7124]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T48849 NZ_CP009419:c1319602-1319324 [Neisseria meningitidis M7124]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT48849 WP_002221020.1 NZ_CP009419:c1319316-1319005 [Neisseria meningitidis M7124]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT48849 NZ_CP009419:c1319316-1319005 [Neisseria meningitidis M7124]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6