Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1289867..1290412 Replicon chromosome
Accession NZ_CP009367
Organism Yersinia enterocolitica strain WA

Toxin (Protein)


Gene name yafQ Uniprot ID A0A8B6KSX9
Locus tag CH47_RS06430 Protein ID WP_005170383.1
Coordinates 1290134..1290412 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A8B6KT24
Locus tag CH47_RS06425 Protein ID WP_005170385.1
Coordinates 1289867..1290127 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH47_RS06385 1285308..1286436 - 1129 Protein_1169 phage tail protein -
CH47_RS06390 1286687..1287229 - 543 WP_005170403.1 phage tail protein I -
CH47_RS06395 1287222..1288130 - 909 WP_005170400.1 baseplate assembly protein -
CH47_RS06400 1288135..1288485 - 351 WP_005170397.1 GPW/gp25 family protein -
CH47_RS06405 1288710..1288853 + 144 Protein_1173 XRE family transcriptional regulator -
CH47_RS06410 1288970..1289290 - 321 WP_005170392.1 hypothetical protein -
CH47_RS06415 1289280..1289486 - 207 WP_005170388.1 host cell division inhibitor Icd-like protein -
CH47_RS23080 1289628..1289795 + 168 WP_005170387.1 hypothetical protein -
CH47_RS06425 1289867..1290127 + 261 WP_005170385.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CH47_RS06430 1290134..1290412 + 279 WP_005170383.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CH47_RS21575 1290455..1290532 - 78 Protein_1179 tail fiber assembly protein -
CH47_RS06435 1290546..1290746 - 201 Protein_1180 Rpn family recombination-promoting nuclease/putative transposase -
CH47_RS06440 1290884..1291513 - 630 WP_005170378.1 phage baseplate assembly protein V -
CH47_RS06445 1291694..1292947 + 1254 WP_005170376.1 hypothetical protein -
CH47_RS06450 1292944..1293984 + 1041 WP_005170374.1 hypothetical protein -
CH47_RS06455 1294028..1294486 - 459 WP_005170370.1 phage virion morphogenesis protein -
CH47_RS06460 1294483..1294938 - 456 WP_005170367.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - pilW / pilW / ail 1267092..1327104 60012


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 11033.77 Da        Isoelectric Point: 9.8470

>T48838 WP_005170383.1 NZ_CP009367:1290134-1290412 [Yersinia enterocolitica]
MTKQREIEYSGQFQKDVKKAQKRHKDMNKLKVIMTLLINDKLPLPVVYKDHQLQGNYKGYRDAHIEPDWLIIYKITDDLL
RFERTGSHSDLF

Download         Length: 279 bp

>T48838 NZ_CP009367:1290134-1290412 [Yersinia enterocolitica]
ATGACTAAACAAAGGGAAATTGAATATTCAGGTCAGTTCCAGAAAGATGTGAAAAAAGCTCAGAAGCGCCATAAAGATAT
GAATAAACTTAAAGTCATTATGACGCTTCTGATTAACGATAAATTGCCCTTGCCTGTTGTATATAAGGATCATCAATTAC
AAGGTAATTATAAAGGCTACAGGGACGCACATATAGAGCCAGACTGGCTTATCATCTACAAAATTACTGATGATTTGCTT
CGCTTCGAAAGGACAGGAAGCCATTCTGATCTATTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9307.69 Da        Isoelectric Point: 5.0758

>AT48838 WP_005170385.1 NZ_CP009367:1289867-1290127 [Yersinia enterocolitica]
MAANAFVRARIDETLKNEAAAVLADMGLTVSDLVRITLTKVAREKALPFDLRIPNELTANTIANSDKGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT48838 NZ_CP009367:1289867-1290127 [Yersinia enterocolitica]
ATGGCTGCAAATGCTTTTGTTCGTGCTCGTATAGACGAAACCCTAAAGAATGAAGCCGCTGCTGTACTTGCTGACATGGG
TTTAACCGTATCCGATCTGGTGCGGATAACCTTAACCAAGGTTGCCCGAGAAAAAGCGCTTCCGTTCGATTTGCGTATTC
CTAACGAACTTACAGCTAATACCATTGCCAACAGCGATAAAGGTGTCGATGTCCATAAAGCAAAGGATGCTGATGATCTT
TTTGATAAATTAGGTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B6KSX9

Antitoxin

Source ID Structure
AlphaFold DB A0A8B6KT24

References