Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2466586..2466770 Replicon chromosome
Accession NZ_CP009361
Organism Staphylococcus aureus strain ATCC 25923

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag KQ76_RS12475 Protein ID WP_000482647.1
Coordinates 2466663..2466770 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2466586..2466646 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ76_RS12450 2462096..2462263 - 168 Protein_2360 hypothetical protein -
KQ76_RS12460 2462494..2464227 - 1734 WP_000486507.1 ABC transporter ATP-binding protein/permease -
KQ76_RS12465 2464252..2466015 - 1764 WP_001064828.1 ABC transporter ATP-binding protein/permease -
- 2466586..2466646 + 61 - - Antitoxin
KQ76_RS12475 2466663..2466770 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
KQ76_RS12480 2466904..2467290 - 387 WP_000779351.1 flippase GtxA -
KQ76_RS12485 2467558..2468700 + 1143 WP_001176855.1 glycerate kinase -
KQ76_RS12490 2468760..2469419 + 660 WP_000831298.1 membrane protein -
KQ76_RS12495 2469601..2470812 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
KQ76_RS12500 2470935..2471408 - 474 WP_000456499.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T48804 WP_000482647.1 NZ_CP009361:c2466770-2466663 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T48804 NZ_CP009361:c2466770-2466663 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT48804 NZ_CP009361:2466586-2466646 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References